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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: aknahow who wrote (13683)	5/26/2000 8:03:00 PM
From: Cacaito	Read Replies (1) \| Respond to of 17367

Gw, E.coli O157:H7 most of the time is not recover from the blood/urine/csf/fluids of the body, but rather from the stools, it does not need to get in the body, the lumen of the bowels is enough, there they produce the exotoxin that gets in, bpi will not bind the exotoxin since it is a completely different molecule, similar to the cholera toxin, but different type of damage. Bpi will of course kill a case of E.coli O157:H7 inside the body, still the exotoxin already release will keep the work until neutralized by the body or death. The association with more antibiotics is about the ability of E.coli O157:H7 of surviving in the lumen of the bowels, rest of bacteria is killed but this is good for O157 cause probably one is killing their natural enemies with antibiotics. It is a clear example of survival of the fittest by natural man made selection. O157 is more common in developed countries with lots of grain to feed cows, and lots of antibiotics to feed cows, in Paraguay nobody will give corn to a cow, plenty of grass, and they do not like the bland favor of US meat. Some farms in the US are switching the cows to grass 2-3 weeks before slaughtering to decrease 0157, something similar with the chicken/salmonella connection. So even if one figure out how to give bpi that avoid digestion and goes and kill bacteria in the bowels,one still has the problem of killing the natural enemies of O157, and O157 has other tricks like nice hooks to attach but not invade the cells so the cells do not even notice they are harboring the killer, talking about sleeping with the enemy. Long live grass (the one for the cow, I mean).