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Biotech / Medical : Cistron Biotechnology(CIST)$.30 -- Ignore unavailable to you. Want to Upgrade?

To: Walter Morton who wrote (2710)	9/6/2000 12:27:00 AM
From: Walter Morton	Read Replies (1) \| Respond to of 2742

Latest CIST patent issued 8/16/2000: Issued 8/16/2000 EP1027071A2: ENCAPSULATED IMMUNOMODULATORS USEFUL AS VACCINE ADJUVANTS Issued 8/9/2000 EP456332B1: PURIFIED INTERLEUKIN 1 AND DNA CODING FOR INTERLEUKIN 1 AND THEIR PREPARATION, VECTORS CONTAINING SUCH DNA AND THEIR PREPARATION AND USE IN TRANSFORMING HOSTS TO PERMIT EXPRESSION OF INTERLEUKIN 1 Issued 4/26/2000 AU6413999A1: SUBSTANTIALLY NON-TOXIC BIOLOGICALLY ACTIVE MUCOSAL ADJUVANTS IN VERTEBRATE SUBJECTS (This is the latest Duke University patent that may be a Joint Patent as explained previously in post #2710.) A method of eliciting an immune response against an antigen in a vertebrate subject, the method comprising the steps of providing an antigen-adjuvant composition comprising the antigen and a substantially non-toxic adjuvant molecule having biological activity in mucosal tissues, and administering said antigen-adjuvant composition to the vertebrate subject in a manner such that initial contact occurs in mucosal tissue of the vertebrate subject, whereby an immune response is elicited. Cytokines are preferred adjuvants. Preferred cytokines are interleukin-1.agr. (IL-1.agr.) and interleukin-1ß (IL-1ß). The patent [Duke Patent]above is a new approach to fighting the AIDS virus. Is CIST really only worth about $18 million?

To: Walter Morton who wrote (2710)	9/6/2000 3:51:56 PM
From: Walter Morton	Read Replies (1) \| Respond to of 2742

"JOINT PATENTS" shall mean any patent or patent application that, First, has inventors from both CISTRON and DUKE, and, [I have not found any patents that meet this requirement.] Second, relates to the FIELD, and, Third, has claims protecting the use of a mutant form of IL-1b as an intranasal vaccine adjuvant, and, Fourth, is based on an invention disclosed to DUKE in an Invention Disclosure Form which was assigned File # 1689 and which is incorporated in its entirety as Exhibit A of this AGREEMENT. From CIST's 2/14/2000 10Q FILING One of CIST's latest patents comes from the patent CIST got from Immunex as an out of court settlement.