AFFX: future gorilla?
Business Summary (from S&P): Affymetrix (AFFX), a leader in the field of DNA chip technology, intends to establish its GeneChip system as the platform of choice for acquiring, analyzing and managing complex genetic information in order to improve the diagnosis, monitoring and treatment of disease. It began commercial sales of the GeneChip system for research use in April 1996, and currently sells products to pharmaceutical and biotechnology companies, academic research centers, and clinical reference laboratories. AFFX's GeneChip probe array technology and systems integrate semiconductor fabrication techniques, solid phase chemistry, molecular biology, software and robotics. The system consists of several integrated components: disposable DNA probe arrays containing gene sequences on a chip housed in a cartridge, reagents for use with probe arrays, instruments to process probe arrays, and software to analyze and manage genetic information.
The company is based in Santa Clara, CA, and has 519 employees. Market cap: 4.7B.
Gorilla potential:
1. mass market potential: Today, AFFX sells to research labs. When this technology moves to clinical labs, it will have a market several orders of magnitude larger, to sell into. This technology can be used to: follow the progress of a disease, assess the odds of getting a disease in the future, assess response to treatment. Most diseases, including all cancers, and most chronic illnesses, have a genetic component. That is, certain genes are turned on and off during the disease process, and inheritence strongly influences the odds of getting the disease. The technology AFFX is developing measures this. This can only be done today at tremendous cost, and the results take weeks to come back. AFFX's postage-stamp-size chips hold up to 8000 gene probes, and can give results the same day. 2. proprietary open architecture/ownership of crucial intellectual property: AFFX has licensed its technology to most of the large drug companies. They won a crucial court battle over patents against INCY in 9/99. Anyone developing any DNA microassay must pay AFFX royalties. However, there are potential competitors (Motorola, Celera, Agilent), and the turf wars in the courts are on-going. None of the other companies are anywhere close to AFFX in terms of developing the technology, market share, or ownership of crucial court-tested patents. 3. switching costs: The chips, and all the related scanners, and the software to manage the vast amount of data, are not compatible with other systems. 4. value chain: AFFX has the beginnings of a value chain, as they have licensed the technology to most of the major drug companies, for their genomics research. No value chain exists for clinical applications yet. 5. Tornado potential: revenues (in million $) for years from 1995 on are: 5,12,20,52,97 (actual in 1999), and 185 (estimate for 2000). Revenues for the last quarter were 40 million, compared with 20 million a year earlier. So, the pattern is a rough doubling every 12 months. This was achieved just selling to research labs, academic centers, biotech companies. They dominate that narrow niche. The real mass market hasn't been entered. I'm guessing the Bowling Alley stage is in 2002-2003. 6. Profits: none yet. However, all 8 of the analysts who follow the stock say the company will become profitable in 2001 (EPS range 1.23-0.43). It is not unreasonable to suppose that profits will double year-on-year (along with sales), and then accelerate as the tornado starts. 7. valuation: all I can say is, the stock chart looks a lot like QCOM's: 16 in 8/98. 327 in February 2000. 171 now. P/S is 40.
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