To: Duane L. Olson who wrote (1451 ) 6/28/2000 12:39:00 AM From: E. Graphs Read Replies (1) | Respond to of 4564
The Next Wave of the Genomics Businesstechreview.com >>The Human Genome Project is in the news. But entrepreneurs are already catching the next wave -- 3-D protein structures. The payoff will be drug discovery at genomic speed.<< ________________ And, an interview with Eric Lander... Riding the DNA Railroadtechreview.com >>...TR: What does it mean for the genome project to be finished? LANDER: The truth is that the human genome is going to have all kinds of nasty little bits that are hard to fill in at the end: the middles of chromosomes, called the centromeres, the ends of chromosomes, called the telomeres, and so on. This is not like the transcontinental railroad, where at some point someone is going to nail in the golden spike, and then and only then can you go cross-country. There is no golden nucleotide to be nailed into the double helix at the end. What's important is that every bit of the DNA railroad is already being used today. As of this month, more than 85 percent of the human genome is freely available on the Web. So the notion that biology will be suddenly transformed when we cross a specific finish line is wrong. The point is that biology has already been transformed. The race is over in the sense that everyone is taking the human genome for granted. That is the achievement right now. TR: What are the next big opportunities in genomics? LANDER: Well, let's start with the basic research question, which is how do you use the information in a genome to figure out how physiology really works. The genome is a very elaborate program, and we don't know how to read it. It's as if we have some ancient computer code that was written three billion years ago and now we are trying to figure out what it does. I think what biologists are going to be doing for the next decade is figuring out the circuitry of the genome by monitoring how the 50,000 to 100,000 genes are turned on and off and how all the proteins come on and off in the cell. A lot of technology is going to be needed to do that, so I also think that detector technology [such as gene chips] is going to be a driving force of genomics in the future. I see a real merger of physics, chemistry, biology and computer science to be able to build these detectors and interpret their results....<<