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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Robert K. who wrote (14172)	7/19/2000 3:40:10 PM
From: Bluegreen	Read Replies (1) \| Respond to of 17367

Bob, it was fun. What, Stockdoc thought that since I invited him on the board I wouldn't ping on him? I almost fell out of my chair laughing when Stockdoc accused me of not understanding sepsis when at this point in time NO ONE really understands sepsis or fully understands etiology behind Aminoglycoside therapy in combating gram neg infections. Hopefully everyone understands in regard to sepsis or most other medical conditions............ONLY THEORIES WHICH CAN CHANGE AT ANYTIME!!!! Biotechs are sheer speculation and even though people are eloquent and "seem" to have a handle on things it is still all about making a buck in a tough field. Understanding the science or looking like understanding the science in my opinion is only a SMALL part of making a buck in Biotech. Only my opinions..........sheer speculation.

To: Robert K. who wrote (14172)	7/19/2000 10:03:18 PM
From: Robert K.	Respond to of 17367

The offspring must know something we dont bout protein c>>> >>>>>>>>>>>>>>>>>>(just IMO)_ You know it's kind of hard Just to get along today Our subject isn't cool But he fakes it anyway He may not have a clue And he may not have style But everything he lacks Well he makes up in denial...... He needs some cool tunes Not just any will suffice But they didn't have Ice Cube So he bought Vanilla Ice Now cruising in his Pinto, he sees homies as he pass But if he looks twice They're gonna KICK HIS LILY ASS

To: Robert K. who wrote (14172)	7/22/2000 9:01:18 AM
From: StockDoc	Read Replies (2) \| Respond to of 17367

RK, I did a lot of work in the field. Published all over the place too. Hypothesis-driven experimental work has been very helpful in understanding more about the septic pathway of bacteriemia, cytokine release (e.g., TNF), micro and macrothrombosis, hypoxia, (pos feed back here), multiple organ failure, circulatory failure, death (in this order) in sepsis. One of the bests in the field, Taylor, hypothesized in 1986 that the body's natural anticoagulant, activated protein C, might block the pathway at the thrombosis level. He tested his hypothesis and he found that he was right. I know more about true anticoagulants than BPI. It appears that BPI works at an earlier step of the same pathway and predominantly targets the intruders (bacteria and their products). I'm not really sure about its antithrombotic properties (as far as the molecular mechanism is concerned). Treatment of sepsis involves combination of drugs and modalities in order to interrupt the bad cycle. Besides obligatory combination of potent antibiotics and other stuff, people tried heparin and/or antithrombin, as an anticoagulant, with not much success. Activated protein C appears to be more potent. I still don't think that patent protection of any drug combination is enforceable, unless they're co-administered in the same dosage form (i.e.,packaged together in the same vial). A very-very unlikely event for APC and BPI. I realize that because I'm a bit lazy GW has started something new here: the big clicking contest. He's funny.