To: Q. who wrote (267 ) 7/28/2000 12:10:32 AM From: Jeffrey S. Mitchell Read Replies (1) | Respond to of 445 Re: Vista International's Protection Plus product Today's CCCX PR states:Vista Internatural Products (VIP), a Centre Capital Corp. company... is distributing (3)PROTECTION PLUS(2) a multi-antioxidant, which has the only core formulation endorsed by the National Foundation for Cancer Research (NFCR). This is the first and only core formulation that the NFCR has endorsed. Vista Internatural's web site goes into more detail:The core formulation of Protection Plus was originally developed at the M.D. Anderson Cancer Center, University of Texas. Its combination of multiple antioxidants has been shown to be highly effective in destroying free radicals and is the first such formulation designed on a sustained release basis. Free radicals are associated with oxidative damage to DNA, which has been attributed to enhanced incidence rates of cancer and other immunological and cardiovascular disorders in humans. combinary2000.com However, a 1998 article in M.D. Andersen's OncoLog begs to differ:Using Antioxidants: Read the Road Signs and Yield to CautionAntioxidants, chemicals found in some foods or synthesized in pill form, have been touted as a magic bullet for preventing cancer. But recent studies now suggest that antioxidant supplements--pills or capsules containing synthesized antioxidants--do not live up to their super-vitamin reputation. Stopping Cancer Before It Starts Antioxidants, scientists theorize, neutralize potentially destructive reactive molecules called free radicals before they can attack DNA. By halting free radical assault, antioxidants may stop genetic mutation and thereby prevent cancer. Fruits and vegetables contain many antioxidants. Antioxidants available in pill form include vitamin C, vitamin E, beta-carotene, and the trace mineral selenium. Proponents of antioxidant supplements claim they can help prevent cancer, heart disease, and various degenerative effects of aging. Clearly a large number of people believe these claims. Sales of vitamins C and E, for example, were estimated at $708 million in 1994 alone. Where's the Proof? But is there substantial scientific evidence to back up the marketing claims? Results of recent studies of the effects of antioxidant supplements on preventing various cancers have been mixed. A Finnish study of 29,000 male smokers over six years attempted to determine if taking a high level of antioxidant vitamins (vitamin E or beta-carotene) could reduce lung cancer incidence. The researchers found no benefit from vitamin E and 18 percent more lung cancer among those participants taking beta-carotene. Another study found no evidence that taking vitamin C, vitamin E, or beta-carotene prevented colorectal cancer. A third study of 22,000 physicians over 12 years found no difference in cancer or cardiovascular disease rates between users and nonusers of beta-carotene. Do these studies mean that antioxidant supplements do not prevent cancer? The jury still seems to be out on that question. Writing about the large Finnish study, the New England Journal of Medicine editorialized, "The results . . . do not disprove the potential benefits of antioxidant vitamins, but they do provide timely support for heightened skepticism." Recent data suggest that vitamin E and selenium supplements may reduce the risk of prostate cancer. Plans for a large study to determine supplements' definitive role in prevention are under way. Without clear evidence that these supplements can prevent cancer, the National Cancer Institute maintains its stance of not recommending them. Getting and Following Good Advice Consumers, however, should not despair. Epidemiologic studies show that diets rich in fruits and vegetables that are sources of a variety of micronutrients are associated with a reduced risk of cancer. The U.S. Food and Drug Administration, which also has refused to endorse the health claims of beta-carotene or vitamin E supplements, has concluded that consuming such a diet reduces cancer risk. Why are fruits and vegetables more effective in preventing cancer than supplements? Possibly the answer is that each fruit and vegetable has hundreds of constituents. The protection from disease is likely a result of a combination rather than any single chemical. So how many fruits and vegetables should be eaten each day? Experts urge Americans to eat five to nine servings daily. It's a seemingly simple solution with far-reaching health benefits. But on a typical day half of all Americans reportedly eat no fruit, and only one quarter eat the recommended five servings. Simple changes make the five-a-day rule easy: start the day with fruit juice, have a salad at lunch, and try carrot sticks or a piece of fruit for a snack. Eat a cancer-fighting cruciferous vegetable--cabbage, broccoli, brussels sprouts, or kale--with dinner.With a diet rich in fruits and vegetables, it is possible to reap the cancer-preventing benefits of antioxidants without ever popping a pill. mdanderson.org - Jeff