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Biotech / Medical : Neuroscience -- Ignore unavailable to you. Want to Upgrade?

To: nigel bates who wrote (33)	8/28/2000 1:52:24 PM
From: Pseudo Biologist	Read Replies (1) \| Respond to of 278

Nigel, the following links (available with free registration at least for now) may help some: Bush's review article "Metals and neuroscience" journals.bmn.com Party line by Elan scientists: journals.bmn.com One of many Selkoe's abstracts on the "amyloid hypothesis" ncbi.nlm.nih.gov In fairness to Elan et al, the role of amyloid deposition as cause of AD has always being formulated as a hypothesis and not as a proven fact. I look forward to Scott's informed comment and opinion. (not even) Pseudo (neuro) Biologist -g-

To: nigel bates who wrote (33)	8/28/2000 2:37:06 PM
From: scott_jiminez	Respond to of 278

You're keepin' me hoppin'. I still owe folks that review on AD pharmacopoeia and I've only reviewed one (SGMO) of two (ARIA) articles I've promised for Peter Suzman. Between generating these pearls of wisdom and finding such investment jewels (!) as PTX and DXT, I really should quit my day job. Nein. The perception of the role of heavy metals in AD has had a long a tortured history. The science is often wanting. I'll get back to you on those abstracts. BTW, PB is correct - few AD investigators would claim that amyloid plaques 'cause' (sporadic or non-familial) Alzheimer's disease. OTOH, there are undoubtedly 'camps' or cliques within in the field which assert that amyloid or apolipoprotein E or zinc or ...... is 'more correlative' than the other leads. Orwellian Science 101.