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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Bluegreen who wrote (14756)	9/19/2000 6:07:23 PM
From: Cacaito	Read Replies (1) \| Respond to of 17367

"Because neurological or organ dysfunction had not been prospectively defined and collected as endpoints on the case-report forms, information on their occurrence was captured from the adverse-events report forms." " However, the use of adverse-event data caused problems since it combined a myriad of inconsequential events with major morbidities such as severe amputation. The results of this composite endpoint analysis are included for completeness, but are recognised as methodologically FLAWED and were not included in the prospective trial design NOR AGREED to by the clinical investigators." " Additionally, an analysis of the composite endpoint, including only endpoints that were prospectively defined in the protocol individually (death, amputations, and POPC), and which are the most clinically meaningful, is presented for comparison." I read the full article. The not prospectively design " flawed composite endpoint" was not agreed to by clinical investigators, and it showed one of the worst "p" (p = 0.74) a BIG IRONY cause the prospectively design endpoints when "composite analysis" was done showed a favorable trend p = 0.07, still not the magic 0.05 or less.

To: Bluegreen who wrote (14756)	9/19/2000 6:47:05 PM
From: Cacaito	Respond to of 17367

Albumin was used in 75% of both placebo and rbpi21 groups. Albumin is now suspected of incresing damage in shock patients. I do know that in pediatric burn children albumin used has been shown to be detrimental, many centers in the US use only saline solutions for treatment for volume expansion during low blood pressure, even this must be tempered and the use of drugs to increase blood pressure is preferred in shock without dehydration. Albumin could also bind to almost everything, it will be interesting to know interactions between albumin and rbpi21 and probable effects if any.