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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: aknahow who wrote (14763)	9/19/2000 11:04:55 PM
From: Bluegreen	Respond to of 17367

George, for you and your new AMIGO Cacaito>>>>>>>>>Am J Otol 2000 Sep;21(5):625-30 Inhibition of endotoxin effects on cultured human middle ear epithelium by bactericidal permeability-increasing protein. Nell MJ, Albers-Op 't Hof BM, Koerten HK, Grote JJ Department of Otorhinolaryngology, Leiden University Medical Center, The Netherlands. HYPOTHESIS/BACKGROUND: Endotoxin can induce morphologic changes to middle ear epithelium, which can disturb the mucociliary clearance system (MCS) and lead to otitis media with effusion (OME). The bactericidal/permeability-increasing (BPI) protein is a major component of neutrophil granules and binds with high affinity to endotoxin. In this study, the capacity to inhibit the effects of endotoxin by rBPI21, a recombinant amino-terminal analog derived from BPI, was investigated on cultured human middle ear epithelium using light microscopy and scanning- and transmission electron microscopy. METHODS: Human middle ear epithelium was air-exposed cultured on a collagenous underlayer with different additions of endotoxin and rBPI21 to the culture medium. The tissue specimens were inspected after 4 weeks for the number of ciliated and secretory cells, thickness of the mucosal layer, and cell size. RESULTS: The morphologic changes induced by endotoxin were increased thickness of the mucosal layer and increased number of secretory cells. These changes were significantly diminished or even absent when endotoxin was added with rBPI21 to the culture medium. CONCLUSION: rBPI21 can inhibit morphologic changes in the middle ear epithelium due to endotoxin. Hence, the authors believe that rBPI21 can be a new therapeutic agent in the treatment of OME.<<<<

To: aknahow who wrote (14763)	9/21/2000 5:30:14 PM
From: Bluegreen	Read Replies (1) \| Respond to of 17367

GEORGE, LOOK AT THIS!!!!!!!!>>>>>>>>>Monkey Business: Primates Pelt Cars .c The Associated Press JARRATT, Va. (AP) - Three monkeys hurled bananas and crab apples at cars on Interstate 95, then fled into the woods, police said. Police believe the monkeys escaped while being taken to the state fair in Richmond or a circus in North Carolina. State Trooper Mike Scott was flagged down Sunday by a driver who had pulled over near Jarratt. ``When I walked up to the car, it looked like a banana had been smeared on the side,'' Scott said. The woman told him a monkey had thrown the fruit about a mile back. ``I started laughing,'' Scott said. But he drove to the scene of the attack and found a van and a station wagon on the side of the highway. ``A man said, `I know this sounds crazy, but a monkey threw an apple at our car,''' Scott said. Just then, something hit the van. ``Lo and behold there were three brown monkeys in an oak tree throwing crab apples,'' Scott said. The primates jumped down, ran across the highway and escaped into more trees. AP-NY-09-21-00 1645EDT<<<<<<<<<<<<<<<<<<<<<<<