To: tom pope who wrote (63 ) 11/4/2000 8:20:05 PM From: smh Respond to of 1784 Don't recall seeing this posted anywhere.kiplinger.com Kiplinger's Magazine September 2000 | INVESTING | STOCKS Picks and Shovels The Payoff for Genebusters Picks and Shovels That's where Van Wagoner's Garrabrant is placing his bets. "We favor companies that sell the enabling technology to discover more about what genes do, now that they've been identified," he says. Those include Affymetrix (AFFX), which makes an array of gene-testing computer chips; Gene Logic (GLGC), which conducts tests to discover the proteins made by specific genes; Millennium Pharmaceuticals (MLNM), which both hires itself out to large pharmaceutical companies to find the most promising targets for drug development and develops gene-based drugs in-house; and Applied Biosystems (PEB), which sells instruments, reagents and software used in biotech research. (For more on Applied Biosystems, see Future Stocks.) Von Emster agrees. "Certainly the picks-and-shovels companies will win first," he says. Four such stocks he favors: Abgenix (ABGX), which creates genetically altered mice and flies for use in research, and which develops monoclonal antibodies as potential drugs; Affymetrix; Exelixis (EXEL), which compares gene sequences in animals and humans to hunt down prospective targets for development; Orchid Biosciences (ORCH), which sells basic chemical reagents needed for genetic research; and scientific-equipment maker Waters Corp. (WAT). Of the highlighted companies, only Applied Biosystems and Waters are profitable, although analysts expect Affymetrix to break into the black in the last three months of this year. They also forecast database sellers Incyte Genomics (INCY) and Human Genome Sciences (HGSI) to generate earnings in 2001 and 2002, respectively. But most genomics companies are trading on hopes and dreams, not results. For now, at least, a more sensible way to dip into the genomics industry may come through a biotech sector fund. For more on two of the past year's top-performing biotech funds, see Go Ahead, Play With Fire. Reporter: Otto Krusius