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Biotech / Medical : Trickle Portfolio -- Ignore unavailable to you. Want to Upgrade?

To: tommysdad who wrote (134)	11/21/2000 12:19:32 AM
From: tuck	Read Replies (1) \| Respond to of 1784

tommysdad, You da Man! Thanks very much. Going to try to get similar shopping lists from miljenko, and perhaps, PseudoBiologist. Any other SI'ers you know practicing in the labs these days? Cheers, Tuck

To: tommysdad who wrote (134)	11/21/2000 3:04:00 AM
From: scaram(o)uche	Respond to of 1784

>> Now you just need a list from some biologists. But I don't think two of them agree on anything! << Chuckle. Chemicals got to his brain. Forgive him. I'm about four years out of date, but some of these are fundamental. Also, I've never done microarrays, HTS, etc. I'd have a bunch of class II biosafety cabinets, Baker or NuAire. Forma incubators. Centrifuges (Sorvall, Eppendorf), Microscopes (largely inverted, Nikon, also Zeiss). Ultralow freezers (Forma, NuAire). Liquid nitrogen freezers too, but I can't remember manufacturer's names. Flow cytometry (BD Immunocytometry), sorters and expendables. Plate readers (Molecular Devices), Beckman counters, a Biacore unit (but I understand that there are inexpensive alternatives now). Like TD, I'd also have a good budget open with VWR, Fisher and Sigma, but it would be dwarfed by that with BD Biosciences (PharMingen/Clonetech), Stratagene, and (third place, so don't get too excited) InVitrogen. Gibco (LTEK, now also InVitrogen) would get tons of my media expense together with other vendors. PCR.... MJ Research, suppliers too numerous to mention (many listed above). Huge budget slice for Qiagen. Plastics.... Corning, Falcon (again BD), Nalge. Tons of money spent here, but they're low margin business?? Jackson Labs and Charles River Labs for mice. Shakers. Lots and lots of shakers. I've left out a ton. Certain that I would have, even if I were still working near a lab.

To: tommysdad who wrote (134)	11/28/2000 11:55:16 AM
From: Dr. Voodoo	Read Replies (3) \| Respond to of 1784

Nice List. This is kinda like Christmas Shopping...Hmmm Maybe my boss will find out! Some thoughts from another angle. I'm a little more expensive so I'd probably take about 5-6M in start up: For my 20 bench chemists I'd want about 1-2 technicians each depending on how good they are: 10 Quest Synthesizers from Argonaut. 300K 1 Irori Tagging system with about, and the washing machine machine that goes with it. ~150K 5,000 tags to go with it 50K. Cans, stations etc. 30K Look around for a high throughput synthesizer I liked, 400K. Partial to the HP LC/MS systems myself. Gilsons for them all too. Probably need 2-3 of em, to run every compound over LC/MS. 480K For sample handling I'd pick up either a Bohdan or HP liquid handling robot, damn biologists want everything done for them.--100K For high througput weighing I'd pick up the Bohdan Weighing station for 80K. For analytical-semiprep HPLC's I'd need about 2 Waters 600 systems with PDA detectors at 50K each, and 2 Waters 600 systems 30K plus 4 Sedere ELS detectors to run in tandem or solo at 15 K each. 220K--Each can run at 20 mL/min, or another 1K gets ya 30ml/min, more than enough to get 100 mgs in a pinch. Columns and stuff 30 K Like 500K for the Varian NMR, or could easily go with Bruker, gotta chuck in an autosampler and pick up a magic angle probe and a few other odds and ends..650K FTIR 50K For HiRes MS I'd send it out. For screening, I'd look into one of those fancy ion-cyclotron 7T jobbies and I'd hire me an expert to put it together. 1-2M I too would find a way to steal my license from MDL. Gotta get the basic stuff like modeling etc plus ACD. Those guys are too proud. Rotovaps computers etc I think I pretty much agree with what ya got. I would buy a few compounds to get me on the dance floor. I want to cherry pick mine. Free is OK. I'd need about 100 K or so per year to handle the chemical informatics, and freezers to put all this stuff I made. FOR BIOLOGY. Since my nice chemists were kind enough to put my stuff in plates all mapped out. I need about 500 K to give to Amersham for running Scintilation proximity assays. I need about 300 K for robotics to handle my part of the liquid handling. I need about 20 biologists to find new targets and design and run new assays. I need a huge pile of money for plastic junk I'm only going to throw away. V