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Pastimes : Triffin's Market Diary -- Ignore unavailable to you. Want to Upgrade?


To: Triffin who wrote (144)2/4/2001 10:04:27 AM
From: Triffin  Respond to of 868
 
PICK: ANK @ 11.25

Two of my favorite things ..
Telecom and paradise ..

March 29, 2000

ATLANTIC TELE NETWORK INC /DE (ANK)
Annual Report (SEC form 10-K)
Federal Trade Commission has issued for comments a proposed rule which could change this. See "Business Regulation". GT&T's agreements with audiotext providers obligate such providers to comply with applicable regulations in the countries in which they advertise their services and to refrain from using obscene or indecent material. From time to time a country's regulatory authorities or national telecommunications carrier have taken steps to restrict or eliminate international audiotext traffic.
Domestic Service. At December 31, 1999, GT&T had approximately 64,000 subscriber access lines in service. This number of access lines represents approximately 8 lines per 100 inhabitants. Of all lines in service, 85% were in the largest urban areas, consisting of Georgetown, Linden, New Amsterdam, Diamond and Beterverwagting. During 1999, GT&T extended service to a number of small communities. However, most rural areas still do not have telephone service.

In the past, GT&T's revenues from local telephone and other services have not been significant (e.g. in 1997 local service revenues amounted to approximately $2.9 million). In December 1997 and October 1998, GT&T applied for rate increases to enable it to earn a 15% rate of return on its rate base. In response to GT&T's December 1997 application, the PUC granted GT&T a temporary rate increase in January 1998, which was subsequently reduced by the PUC in March 1998, pending a final decision on GT&T's application. As a result of the temporary rates for local service in effect throughout most of 1998 and all of 1999, GT&T's local service revenues increased to approximately $9.4 million in 1998 and $8.7 million in 1999.

GT&T's revenues for local service are derived from installation charges for new lines, monthly line rental charges, monthly measured service charges based on the number and duration of calls and other charges for maintenance and other customer services. For each category of revenues, rates differ for residential and commercial customers. Residential and commercial customers have contributed approximately equally to GT&T s revenues from local service. As of the end of 1999, GT&T's basic monthly charge per access line was approximately $1.40 for residential customers and approximately $5.55 for business customers, and the average monthly bill for residential and business service (excluding charges for international calls and cellular service) was $7.13 and $15.06, respectively.

GT&T currently provides mobile cellular telephone service in the Georgetown area and along a portion of Guyana's coastal plain. GT&T plans to complete cellular coverage of the coastal plain in 2000. Cellular subscribers are offered various calling plans and are charged a monthly fee plus airtime based on the selected plan. GT&T's current average monthly charge per cellular subscriber is approximately $63.99, including monthly rental and airtime charges. As of December 31, 1999, GT&T had approximately 2,900 active mobile cellular subscribers.

Expansion. Since the Company acquired its interest in GT&T in January 1991, GT&T has significantly expanded and rebuilt its telecommunications network. The number of access lines has increased from approximately 13,000 working lines in January 1991 to approximately 64,000 lines at December 31, 1999. Substantially all of GT&T's access lines are now digitally switched lines. The Intelsat B earth station, which provides the principal link with Guyana and the rest of the world, was upgraded and digitalized to increase the number of available circuits from 75 in January 1991 to 1,266 currently. In 1997, GT&T installed a second Standard B earth station, which is currently used to provide service through an Intelsat satellite to a number of localities in the interior of Guyana. This earth station and the Intelsat satellite may also be used in the future to provide a second satellite link from Guyana for international traffic.

In the second quarter of 1997, GT&T completed a test installation of a Northern Telecom Proximity I fixed wireless network in a rural area about 60 kilometers west of Georgetown. GT&T currently utilizes this technology to provide wireless telephone service to about 1,800 subscribers in this area. The installation of these services began in December 1999 and will continue through the first quarter of 2000. The normal rates for land line telephones apply to GT&T's fixed cellular and fixed wireless network services.

GT&T has installed over 400 public telephones in locations across the country providing telecommunications for both local and international calls in areas that had not previously enjoyed service. Currently, in addition to the public telephones, GT&T maintains three public "telephone centers" at which the public can, upon payment of the charges in cash to GT&T personnel who staff these centers, use an ordinary residential-type telephone to make international and domestic calls.

GT&T has purchased capacity in two international fiber optic cables - the Americas I cable, which runs from Brazil to Trinidad, the United States Virgin Islands and the United States mainland, and the Columbus II cable, which runs from the Caribbean region to the Azores and Spain. The Company is presently participating with other international carriers to build a third cable, Americas II, that would provide a leg to Guyana, Suriname and French Guyana. Americas II is planned to be operational by May 2000.

If and when GT&T's current regulatory and tax issues are resolved, the Company anticipates that GT&T will further significantly expand its facilities. GT&T is currently involved in a proceeding with regard to delays in completing its original expansion program (the "Expansion Plan") and is subject to a PUC order requiring additional expansion of services that GT&T has not met. See "Business Regulation".

Other Services. GT&T is also licensed to provide various telephone-related services that extend beyond basic telephone service, including yellow pages and other directory services, and it has an exclusive license to sell, lease or service various kinds of telecommunications equipment. Under its license from the Government of Guyana (the "License"), GT&T's rates for most of these services must be specified in a tariff approved by the PUC. See "BusinessRegulation."

Significant Revenue Sources

Revenues from the following carriers of international traffic to Guyana constituted the following percentages of GT&T's revenues in the past three years:

1997 1998 1999
AT&T................................... 31% 27% 24%
MCI 11% 11% 18%
British Telecom........................ 9% 9% 8%
Teleglobe (Canada)..................... 18% 18% 14%

A significant portion of GT&T's international long distance revenue discussed above is generated by certain of GT&T's audiotext providers which operate as service bureaus or intermediaries for a number of audiotext information providers. The following service bureaus accounted for more than 10% of GT&T's total revenues in the years indicated below:

1997 1998 1999
Beylen Telecommunications, Ltd. 33% 20% 14%
Islands Telephone Company Limited 15% 11% 6%

No other revenue source accounted for more than 10% of GT&T's total revenues in 1997, 1998 or 1999.
Competition

Pursuant to its franchise from the government of Guyana, GT&T has the exclusive right to provide, and is the sole provider of, local, domestic long-distance and international telephone service in Guyana, except for cellular radio telephone service. One other company began providing local, mobile cellular service near the end of 1998. Another company has been seeking a license to provide fixed wireless service as well as mobile service and to provide wireless international services. GT&T has been opposing this application to the extent it goes beyond local, mobile wireless service on the grounds that the other services are within the exclusive rights granted GT&T in its franchise.

GT&T has the exclusive franchise to provide telephone directories and directory advertising and to supply a wide variety of telecommunications equipment in Guyana. GT&T's revenues from directory advertising and the sale of telecommunications equipment have not been significant to the Company.

The provision of telecommunication services to international audiotext providers is highly competitive. GT&T competes with many telephone companies around the world that provide telecommunications services to international audiotext providers. GT&T's contracts with audiotext providers are all terminable on short notice, and such providers can quickly shift their traffic to another foreign telecommunications carrier which offers higher compensation or better services merely by changing the telephone numbers in their advertisements. . Regulation

GT&T is subject to regulation in Guyana under the provisions of its License and under the Guyana Public Utilities Commission Act of 1999 ("PUClaw") and the Guyana Telecommunications Act 1990 ("Telecommunications Law"). GT&T also has certain significant rights and obligations under the agreement (the "GT&T Agreement") pursuant to which the Company acquired its interest in GT&T in 1991.

License. The License, which was issued on December 19, 1990, grants GT&T an exclusive franchise to provide in Guyana (i) for a period of 20 years (renewable for an additional 20 years at the option of GT&T), public telephone, radio telephone (except private radio telephone systems which do not interconnect with GT&T's network) and pay station telephone services and national and international voice and data transmission, sale of advertising in any directories of telephone subscribers and switched or non-switched private line service; and (ii) for a period of 10 years (renewable for an additional 10 years on a non-exclusive basis at the option of GT&T) supply of terminal and customer premises equipment and telefax, telex and telegraph service and telefax network service (without prejudice to the right of any other person to undertake any of the following activities: (a) sale of telefax or teleprinter machines, (b) maintenance of telefax or teleprinter equipment, or (c) operation of any facility for the sending or receiving of telefax copies or teleprinter messages). In addition, GT&T was granted a non-exclusive license to provide, for a period of 20 years (renewable for an additional 20 years at the option of GT&T), cellular radio telephone service.

GT&T Agreement. Under the GT&T Agreement GT&T undertook to complete a substantial Expansion Plan by a date which, after giving effect to certain agreed upon extensions, was February 28, 1995, and GT&T was entitled to a specified minimum return. Subject to certain limitations applicable to the years 1991-1994, GT&T is entitled, pursuant to the GT&T Agreement, to a minimum return of 15% per annum on its capital dedicated to public use ("rate base"). Absent mutual agreement by the government of Guyana and the Company (and there has been no such agreement) on a rate of return methodology, rates are to be calculated on the basis of GT&T's entire property, plant and equipment pursuant to a rate of return methodology consistent with the practices and procedures of the United States Federal Communications Commission. GT&T believes that its rate base at December 31, 1999 was approximately $108.8 million, although the PUC in various orders or staff reports has thrown out or challenged several million dollars of franchise rights and working capital which are included in the foregoing figure. GT&T believes that its 15% per annum minimum return is to be calculated after all of GT&T's operating expenses (including income taxes) other than interest expense. However, the PUC has disallowed as an expense for rate making purposes management fees equal to 6% of GT&T's revenues which GT&T pays to the Company pursuant to an agreement approved by representatives of the government at the time of the Company's acquisition of its interest in GT&T.

Under the GT&T Agreement, upon non-renewal or termination of the License, the government of Guyana will be entitled to purchase the Company's interest in GT&T or the assets of GT&T upon such terms as may be agreed to by the Company and the government or, absent such agreement, as may be determined by arbitration before the International Center for the Settlement of Investment Disputes.

PUC Law and Telecommunications Law. The PUC Law and the Telecommunications Law provide the general framework for the regulation of telecommunications services in Guyana. The Public Utilities Commission of Guyana ("PUC") is an independent statutory body with the principal responsibility for regulating telecommunications services in Guyana. The PUC has authority to set rates and has broad powers to monitor GT&T's compliance with the License and to require GT&T to supply it with such technical, administrative and financial information as it may request. The PUC also has broad authority to review and amend any GT&T program for development and expansion of facilities or services.

Although, under the current PUC Law and predecessor statutes which have been in effect since 1990, the PUC is obligated to honor the provisions of the GT&T Agreement on rates, in the Company's opinion, the PUC has consistently failed to do so:

o In April 1991, GT&T sought a 184% rate increase to which it was entitled under the GT&T Agreement to compensate for a devaluation of the Guyana currency. The PUC delayed its decision until November 1991 when it awarded only a part of the increase sought, and then further delayed authorizing GT&T to collect various portions of the increased rates until 1995. A small portion of the increased rates awarded in November 1991 was never authorized for collection.

o In May 1995, GT&T applied to the PUC for a substantial increase in all of its local rates to enable it to earn the minimum 15% return specified in the GT&T Agreement. In October 1995, the PUC rejected GT&T's application and substantially reduced rates in an order ultimately voided by the Guyana High Court on grounds that the PUC's hearing procedures violated "principles of natural justice."

o On December 31, 1997, GT&T again applied to the PUC for a significant increase in rates so as to enable GT&T to earn a 15% return on its rate base. The PUC first awarded GT&T on a temporary basis a substantial increase in rates and then without holding any hearings, as are required under the PUC Law, some ten weeks later, ordered a substantial reduction in the interim rate increase.

o On October 27, 1998 to reflect changed conditions since December 31, 1997, GT&T filed for an additional rate increase designed to generate $19.0 million in additional revenues over and above the interim rates currently in effect. GT&T's two applications for a permanent rate increase are still pending before the PUC.

o In January 1999, the chairman of the PUC held a press conference which dealt extensively with the rate issues under consideration by the PUC. GT&T applied to the Guyana High Court for an order prohibiting the chairman from further participation in the rate case on the grounds that this press conference and his statements at the press conference revealed a predetermination and bias by the chairman against GT&T on the pending issues. In response to this application, the Guyana High Court issued an order directing the chairman and the PUC to show cause why such an order of prohibition should not be issued. In the Company's opinion, the Guyana High Court's order had the legal effect of barring the chairman, but not the other members of the PUC, from further participation in the rate case pending a determination by the Guyana High Court of the merits of GT&T's application. The PUC, however, took the position that all of its members were barred from further participation in the rate case during the pendency of the High Court's order to show cause, and the PUC declined to schedule any further hearings in the rate case. On March 28, 2000, the High Court found that the chairman's statements at the press conference provided a reasonable basis to suspect the chairman of having a bias against GT&T, and the Court barred the chairman of the PUC from further rate case proceedings.

In addition to the two pending rate cases, GT&T has a number of other significant matters pending before the PUC:

o Since March 1995 the PUC has had pending a proceeding initiated by the minister of telecommunications of Guyana, with regard to the noncompletion of the Expansion Plan by its scheduled completion date of February 28, 1995. It is GT&T's position that its failure to receive timely rate increases, to which GT&T was entitled, to compensate for the devaluation in Guyana currency which occurred in 1991 provides legal justification for GT&T's delay in completing the Expansion Plan. If the PUC concludes that GT&T failed or refused to complete the Expansion Plan in a timely manner without legal justification, it may impose a fine, which could range from $56 (G $10,000) up to the cost of completing the portion of the Expansion Plan which was unfinished on February 28, 1995 (which GT&T estimates to be no more that $5 million). The PUC could also recommend to the government that it cancel the License. The Guyana government is not bound to act on a PUC recommendation. GT&T will have the right of appeal to the Guyana courts from any adverse ruling of the PUC.

o In October 1997, the PUC ordered GT&T to increase the number of telephone lines in service to a total of 69,278 lines by the end of 1998, 89,054 lines by the end of 1999 and 102,126 by the end of the year 2000, to allocate and connect an additional 9,331 telephone lines before the end of 1998 and to provide to subscribers who request them facilities for call diversion, call waiting, reminder call and three-way calling by the end of the year 1998. In issuing this order, the PUC did not hear evidence or make any findings on the cost of providing these lines and services, the adjustment in telephone rates which may be necessary to give GT&T a fair return on its investment or the ways and means of financing the requirements of the PUC's order as required by the PUC Law then in effect. GT&T has filed a motion against the PUC's order in the Guyana High Court and has appealed the order on different grounds to the Guyana Court of Appeal. No stay currently exists against this order, and the PUC has recently scheduled a hearing to inquire into GT&T's compliance or noncompliance with this order.

o In July 1998, the PUC gave notice that it would hold a public hearing on August 25, 1998 in respect of the following matters; (i) "the validity of the grant of monopoly rights to any owner or provider of services in the public utility sector, having regard to the laws in force in Guyana at the relevant time;" and (ii) "whether the Commission has power to request the Government to issue a license to a new provider of services in the public utility sector, where the existing provider in that sector fails to refuse to meet reasonable demands for service in that public utility sector." While the PUC's notice did not name GT&T as the service provider in question, the Company believes that GT&T is the service provider which will be the subject of the hearing. This intended hearing has been stayed by an order issued by the Guyana High Court on an application by GT&T pending a hearing on the merits of GT&T's application.

o In 1997 after the Guyana High Court voided a PUC order of October 1995 reducing GT&T's rates for outbound long distance calls to various countries, GT&T put into effect a surcharge to recover the approximately $9.5 million of lost revenues from the period of October 1995 to the date of the High Court's order. The Guyana Consumer Advisory Bureau, a non-governmental group, instituted a suit challenging GT&T's rights to institute this surcharge without PUC approval, and in the fourth quarter of 1999, the Guyana High Court ruled that GT&T should have first obtained PUC's permission for such surcharge. Substantially all of the $9.5 million of lost revenues were collected prior to the court's ruling, and it is unclear whether GT&T will be required to make any refund since the High Court did not rule on GT&T's contention that it was entitled to recover these lost revenues.

o In February 2000 GT&T received notices of five separate hearings from the PUC relating to various issues, including GT&T's failure to comply with the October 1997 order to increase the number of lines in service, and information requests on the amount of surcharges collected by GT&T as a result of the High Court's voiding of the PUC's October 1995 rate reduction order. GT&T has filed with the Guyana High Court a petition to bar the Chairman of the PUC on the grounds of bias from participating in any matters involving
GT&T.

At the date of this report, the fixed term of office of all of the members of the PUC has expired, and the government of Guyana has the authority to replace any or all of the members.

FTC Matters. On October 30, 1998, the U.S. Federal Trade Commission ("FTC") issued for comment a proposed rule which would expand the definition of "pay-per-call" services to include international audiotext services such as those which GT&T terminates in Guyana. If adopted in its present form the FTC's proposed rule would require, among other things, that a caller must receive a short preamble at the beginning of the call advising the caller of the cost of the call and permitting the caller to terminate the call without charge if terminated immediately. Although GT&T has not completed its study of the ways and means of possibly complying with this requirement, it may be technically impossible for recipients of international audiotext traffic, such as GT&T, to separate audiotext traffic from other incoming international traffic and permit a free preamble for audiotext calls. The FTC's proposed rule would have the effect of prohibiting a local telephone company from disconnecting a subscriber's telephone service for failure to pay charges for an international audiotext call. This requirement currently applies to area code 900 domestic audiotext. The proposed rule would also include several requirements which, if adopted, could make it more difficult to bill and collect for international audiotext calls. If the proposed regulations are adopted, they may have a significant adverse impact on international audiotext traffic from the United States to Guyana and other non-U.S. termination points.

FCC Matters. The U.S. Federal Communications Commission ("FCC") has issued a Report and Order in a rule making proceeding in which it adopted mandatory international accounting and settlement rate benchmarks for many countries. The FCC adopted a mandatory settlement rate benchmark of $.23 per minute for low-income countries such as Guyana and required that settlement rates between the U.S. and low-income countries be reduced to $.23 per minute by January 1, 2002. The current settlement rate is $.85 per minute. The FCC stated in the Report and Order that it expects U.S. licensed carriers to negotiate proportionate annual reductions prior to 2002.

In accordance with this FCC policy, AT&T sought a reduction in the settlement rate for traffic between Guyana and the United States, GT&T declined to agree to such a reduction, and effective December 31, 1999 GT&T's operating agreement and all direct circuits with AT&T were terminated. In anticipation of the termination of the AT&T agreement, GT&T has sought to bring on circuits with other carriers to handle the traffic previously received from AT&T and to restructure its operating agreements with carriers around the world so that GT&T will receive approximately $.85 per minute as a termination fee for international traffic from all countries, with the exception of Canada and certain Caribbean countries which will continue to be able to send normal volumes of traffic to GT&T at the lower rates which traditionally have been in effect with these countries.

It is likely that international settlement rates between Guyana and the United States and other countries around the world will decline significantly on or prior to January 1, 2002. Any significant reduction in the settlement rates for U.S. - Guyana traffic could have a significant adverse impact on GT&T's earnings. While such an event would provide GT&T with basis to seek a rate increase from the PUC so as to permit GT&T to earn its contractually provided 15% rate of return, there can be no assurances as to when or whether GT&T would receive such a rate increase.

Taxation -United States

As a U.S. corporation, the Company is subject to U.S. federal income tax on its worldwide net income, currently at rates up to 35%. GT&T is a controlled foreign corporation ("CFC") for purposes of the Subpart F provisions of the Internal Revenue Code of 1986, as amended (the "Code"). Under those provisions, the Company may be required to include in income certain earnings and profits ("E&P") of a CFC subsidiary at the time such E&P are earned by the subsidiary, or at certain other times prior to their being distributed to the Company. At present, no material amount of such subsidiary E&P is includible in the U.S. taxable income of the Company before being distributed to it. Pursuant to the foreign tax credit provisions of the Code, and subject to complex limitations contained in those provisions, the Company would be entitled to credit foreign withholding taxes on dividends or interest received, and foreign corporate income taxes of its subsidiaries paid with respect to income distributed as dividends or deemed distributed under Subpart F from such subsidiaries, against the Company's U.S. federal income tax.

A U.S. corporation is classified as a Personal Holding Company ("PHC") if (a) more than 50% of its capital stock is owned directly or indirectly by or for five or fewer individuals (or pension plans); and (b) at least 60% of its adjusted ordinary gross income consists of certain types of income (principally passive income, including interest and dividends) included in the Code definition of "PHC Income." For any taxable year that a corporation is a PHC, the "undistributed personal holding company income" of such corporation for that year (i.e., the net income of the corporation as reflected on its U.S. corporate income tax return, with certain adjustments, minus, in general, federal income tax and dividends distributed or deemed distributed for this purpose) would be subject to an additional PHC tax of 39.6%. The Company currently satisfies the above ownership criterion but the Company believes that it does not satisfy the income criterion for classification as a PHC. Taxation - Guyana

GT&T's worldwide income is subject to Guyanese tax at an overall rate of 45%. The GT&T Agreement provides that the repatriation of dividends to the Company and the payment of interest on GT&T debt denominated in foreign currency are not subject to withholding taxes. It also provides that fees payable by GT&T to the Company or any of its subsidiaries for management services they are engaged to render shall be payable in foreign currency and that their repatriation to the United States shall not be subject to currency restrictions or withholding or other Guyana taxes.

In May 1997, GT&T received a letter from the Guyana Commissioner of Inland Revenue indicating that GT&T's tax returns for 1992 through 1996 had been selected for an audit under the direct supervision of the Trade Minister with particular focus on the withholding tax on payments to international audiotext providers. In March and April 1997, the Guyanese Trade Minister publicly announced that he had appointed a task force to probe whether GT&T should pay withholding taxes on fees paid by GT&T to international audiotext providers. The Minister announced that if GT&T were found guilty of tax evasion it could owe as much as $40 million in back taxes. In July 1997, GT&T applied to the Guyana High Court for an order prohibiting this audit on the grounds that the decision of the Minister of Trade to set up this task force and to control and direct its investigation was beyond his authority, violated the provisions of the Guyanese Income Tax Act, interfered with the independence of the Commissioner of Inland Revenue and was done in bad faith, and the court issued an order effectively staying the audit pending a determination by the court of the merits of GT&T's application.

In June 1997, GT&T received an assessment of the current equivalent of approximately $3 million from the Guyana Commissioner of Inland Revenue for taxes for 1996 based on the disallowance as a deduction for income tax purposes of five-sixths of the advisory fees payable by GT&T to the Company and for the timing of the taxation on certain surcharges to be billed by GT&T. The deductibility of these advisory fees and the deferral of these surcharges until they are actually billed had been upheld for an earlier year in a decision of the High Court in August 1995. In July 1997, GT&T applied to the High Court for an order prohibiting the Commissioner of Inland Revenue from further proceeding with this assessment on the grounds that the assessment was arbitrary and unreasonable and capriciously contrary to the August 1995 decision of the Guyana High Court, and GT&T obtained an order of the High Court effectively prohibiting any action on the assessment pending the determination by the court of the merits of GT&T's application.

In November 1997, GT&T received assessments totaling the current equivalent of approximately $11 million from the Guyana Commissioner of Inland Revenue for taxes for the years 1991 through 1996. It is GT&T's understanding that these assessments stem from the same audit commenced in May 1997 which the Guyana High Court stayed in its July 1997 order referred to above. Apparently because the audit was cut short as a result of the Court's July 1997 order, GT&T did not receive notice of and an opportunity to respond to the proposed assessments as is the customary practice in Guyana, and substantially all of the issues raised in the assessments appear to be based on mistaken facts. GT&T has applied to the Guyana High Court for an order prohibiting the Commissioner of Inland Revenue from enforcing the assessments on the grounds that the origin of the audit with the Minister of Trade and the failure to give GT&T notice of and opportunity to respond to the proposed assessment violated Guyana law. The Guyana High Court has issued an order effectively prohibiting any action on the assessment pending the determination by the Court of the merits of GT&T's application.

EOM -------------------------------------------------------

siliconinvestor.com



To: Triffin who wrote (144)2/11/2001 1:02:07 PM
From: Triffin  Read Replies (1) | Respond to of 868
 
BC: HUPO & PROTEOMICS

HUPO Announces Its Formation With the Creation of a Global Senior Advisory Group
LONDON, Feb. 9 /PRNewswire/ -- HUPO (The Human Proteome Organisation) is pleased to announce its launch today with the official formation of a global advisory council which brings together world leading expertise in the field of proteomics from both the academic and commercial sectors.

The reason for creating HUPO is to assist in increasing the awareness of this discipline of science across society, particularly with regard to the Human Proteome Project and to engender a broader understanding of the importance of proteomics and the opportunities it offers in the diagnosis, prognosis and therapy of disease. As a global body it will also have the objective of fostering international cooperation across the proteomics community and of promoting scientific research in an on-going manner around the world.

In addition to the scientific fraternity, governmental and financial constituencies will be a focus of HUPO. Both these communities will be important participants in ensuring that the substantial benefits that will result from proteomics are to be fully taken advantage of and capitalised on.

The advisory council has membership from across Europe, North America, the Far East and Japan and all the members are long-term contributors in the field of proteomics. Collectively this group of industry representatives undoubtedly represents the world's leading pool of expertise and knowledge in this arena. A list of council members is set out in the notes to editors. It is intended that the membership of the organisation will grow to incorporate various disciplines and funding agencies likely to impinge on proteomics in the future.

In addition, special task forces have been established in Europe and Japan to represent HUPO at a regional level. These are headed-up respectively by Prof. Julio Celis of the University of Aarhus and Prof. Akira Tsugita of the Science University of Tokyo.

An inaugural meeting of HUPO, which will be open to individuals interested in proteomics, will take place between April 2-4, 2001 in Virginia, USA. At this meeting the Human Proteome Project will be discussed, the detailed goals and objectives of HUPO will be considered and nominations sought for an inaugural president.

Proteomics is in essence the study of the function, regulation and expression of proteins in relation to the normal function of the cell and in the initiation or progression of a disease state. Proteomics is of particular importance as it is at the level of protein activity that most diseases are manifested. Consequently proteomics seeks to correlate directly the involvement of specific proteins and /or protein complexes in a given disease state.

The applications for proteomics are considerable:

* Specific proteins can be identified as highly accurate and sensitive
markers for disease at a very early stage of onset, thus ensuring their
utility in a diagnostic capacity.

* Proteins are important in the prognosis and in the monitoring of
therapeutic treatments, as the under or over expression of proteins
identified as being disease markers reduces with the improvement in a
disease condition. An important potential application here is in
increasing the speed and efficacy of clinical trials.

* A knowledge of protein expression patterns can provide insight into
potential toxic side-effects during drug screening and lead
optimisation.

* Proteins identified as being relevant in specific disease conditions
could be valid targets for therapeutic agents and thus could have an
important role in the development of new therapeutic treatments.

The near completion of the Human Genome Project has served to underline the importance of proteomics, as now that the human genome has been sequenced it is the understanding of proteins, the products of genes, in the context of disease genesis that is the next logical step to take. It is important to appreciate that whilst each gene produces one to several proteins, that these are in turn further modified by the cellular machinery which results in the proteome being a far more complex and dynamic entity than a genome. The protein products behave differently in different tissues and facilitate separate function from the same genome. Therefore whilst the genome is fundamental in providing the building blocks of Life, it is the proteins that do the work.

The importance of genomics is already well appreciated as is evidenced by the multi-billion dollar research effort it has spawned as well as numerous commercial success stories. HUPO recognises that proteomics now warrants a similar focus of investment and research effort and will work hard to assist in creating a similar environment for proteomics. HUPO will work in close collaboration with its equivalent in the genomics field, HUGO (Human Genome Organisation), as the two areas of science are very closely interlinked and complementary to one another. It is planned that many joint initiatives will be developed out of the existing HUGO infrastructure.

One of the founder members of HUPO, Prof. Ian Humphery-Smith of the University of Utrecht and Glaucus Proteomics said:

``Proteins are central to our understanding of cellular function and disease processes and without a concerted effort in proteomics the fruits of genomics will go unrealised. The necessity of proteomics cannot be avoided -- over the last year alone some very significant advances clearly vindicate this view.

``It is our aim at HUPO to facilitate a greater awareness of such developments, to further the understanding of proteomics and to encourage cooperation between the scientific, governmental and financial communities in order to realise the full benefits that proteomics can deliver.''

Prof. Sam Hanash from the University of Michigan, USA added:

``In the field of cancer research, proteomics will very likely fill an unmet need for reliable markers that allow early diagnosis to be made. Also proteomics will likely provide a multitude of novel targets for chemoprevention and therapy, as we understand the role of protein modifications and protein-protein interactions in diseases.''

Prof. Joachim Klose of Humboldt University in Germany, a researcher with over 25 years experience in the field of proteomics, noted:

``Proteome analysis will only contribute substantially to our understanding of complex human diseases like cancer and cardiovascular diseases, if a worldwide endeavour is initiated aiming at a systematic characterisation of all human proteins with regard to such fundamental biological properties as tissue cell organelle specificity, developmental stage and age specificity and genetic variability among human individuals.''

The following individuals are the inaugural council members of HUPO:

Ruedi Aebersold: raebersold@systemsbiology.org; The Institute for Systems
Biology; +1-206-732-1200

Amos Bairoch: amos.bairoch@isb-sib.ch; Swiss Institute of Bioinformatics;
+41-22-702-5860

Michael Dunn: Mike.Dunn@harefield.nthames.nhs.uk; National Heart and Lung
Institute, Imperial College School of Medicine; +44-1895-828-890

Julio Celis: jec@biokemi.au.dk; Univeristy of Aarhus; +45-8942-2887

Sam Hanash: shanash@umich.edu; University of Michigan; +1-734-763-9311

Denis Hochstrasser: Denis.Hochstrasser@dim.hcuge.ch;
University of Geneva & GeneProt; +41-22- 372-7355

Ian Humphery-Smith: i.humphery-smith@pharm.uu.nl;
University of Utrecht & Glaucus Proteomics; +31-61-50-11-278

Peter James: peter.james@elmat.lth.se; Lund University; +41-1724-3249

Joachim Klose: klose@charite.de; Humboldt-Universitat; +49-30-450-66133

Joshua LaBaer: joshua_labaer@hms.harvard.edu; Harvard Medical School;
+1-617-432-2659

Hanno Langen: hanno.langen@roche.com; F.Hoffmann-La Roche; +41-61-6882-758

Matthias Mann: mann@bmb.sdu.dk; University of Southern Denmark & MDS
Proteomics; +45-6550-2364

Kazuyuki Nakamura: nakamura@po.cc.yamaguchi-u.ac.jp; Yamaguchi University;
+81-836-22-2212

Raj Parekh: raj.parekh@ogs.co.uk; Oxford GlycoSciences; +44-1235-208-000

Scott Patterson: scott.patterson@celera.com; Celera Genomics;
+1-240-453-3000

Christopher Pearce; psplc@compuserve.com; Proteome Sciences Plc;
+44-1932-865-065

Peter Roepstorff: roe@PR-Group.sdu.dk; University of Southern Denmark;
+45-6550-2404

Richard Simpson: Richard.Simpson@ludwig.edu.au ; Ludwig Institute for
Cancer Research & Walter and Eliza Hall Institute for Medical Research;
+61-3-9341-3155

Ian Tomlinson: imt@mrc-lmb.cam.ac.uk; MRC Laboratory of Molecular Biology;
+44-1223-402-103

Akira Tsugita: tsugita@proteo.gr.jp; Science University of Tokyo,
+81-298-51-1601

John Yates: jyates@scripps.edu; Scripps Research Institute;
+1-858-784-8862

EOM -------------------------------------------------------