To: software salesperson who wrote (632 ) 1/24/2001 9:14:18 PM From: scaram(o)uche Read Replies (2) | Respond to of 3044 5. impressions - - sounded like the analyst community bought into the profitability model. i'd be interested in other listeners' takes on the profitability discussion They can (and, IMO, will) generate the NMEs at that rate. Partnership models will be 50:50 for the foreseeable future. The LKST deal was a "win-win model". This all adds up to big-time leverage. If they can make some additional CEOs pay attention to the win-win potential and add breadth to the late-stage pipe, they'll add even more leverage. Pretty soon, MLNM-like vision and MLNM-like guts will add up to a real threat, even to the very strongest of pharmas. The proposed "scratch my back and I'll scratch yours" route to profitability? Every divisional president known to man will line up for a view. Levin, Tepper et al. will look for strong sales growth, complemented by a weak pipe. Why will it work? They have 300M plus rolling through their research labs. Their research is MUCH more efficient than the pharma partners. Assume that resources on the pharma side for any 50:50 deals are about 2X (I've worked in both a pharma organization - Bayer - and biotechs). That's a lot of $$$ thrown at highly efficient research, where many pharmas are way behind on the learning curve. A couple of years ago (or so) -- here at SI -- I said that I considered MLNM to be one of the top three research organizations, worldwide. There was some scoffing, but no LOL. I doubt that many would scoff now. Markets will become much more fragmented, and blockbusters will have shorter market life spans. MLNM is perfectly situated to be a big winner. The "snowball" model for the anti-inflammatory business evolved EXACTLY as Levin predicted. As a result of such vision, there are young senior scientists who, despite having arrived late, are sporting options worth a bundle. MLNM is going to do everything in their power to bring the Microsoft model of motivation to biotech, and they're batting 100% thus far. A clever idea for venture capitalists? Find the correct munch companies, and "buy out" the CEOs and Boards. Install MLNM-friendly puppets. :-) i'd be interested in other listeners' takes Oooops, haven't listened yet. This was all off the cuff BS. Never mind. Again, as for each quarter, thanks for your report!