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Biotech / Medical : Biotech Valuation -- Ignore unavailable to you. Want to Upgrade?

To: Ian@SI who wrote (2999)	2/26/2001 7:18:30 PM
From: Michael Young	Read Replies (1) \| Respond to of 52153

Started a position in SCIO today. I like what I'm reading regarding the potential for Natrecor. MIKE

To: Ian@SI who wrote (2999)	2/26/2001 8:03:06 PM
From: Biotech Jim	Read Replies (2) \| Respond to of 52153

Ian and Peter- As to junk cDNAs, there really is no such thing since all "real" cDNAs come from mRNAs. Of course some pseudogenes can be transcribed, but either do not have significant ORFs (premature termination codons) or may not have an initiator Met. On the other hand, in the GenBank it is amazing the number of sequences submitted as cDNAs that correspond to the cloning vector sequence per se. So, your comment Peter as to "What do you think of the possibility that some of the cDNA that INCY has in its database is "junk cDNA" (don't know if this is a real term) that is a transcription of a non-gene sequence and/or otherwise does not result in the production of a protein?" is a possibility, though in my experience this "junk" has been largely filtered out. In the classical sense of junk DNA, as per the Wally Gilbert discussion and definition, I don't think you can refer to cDNA as such. Now, to look at the human genome project and the interexon and intergenic DNA, it is clear that the human genome has more such stuff than any other organism in which I am familiar. Does this mean that there is less room for homo sapiens evolution? This might be a good conversation for a group of us geeks after the half barrel is tapped. By the way, I know of two fund managers that were picking up INCY shares today. They feel that the stock is highly undervalued even considering the significant INCY burn planned this year. BJ