Silicon Investor (SI) -- The First Internet Community

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Gold/Mining/Energy : Nuvo Research Inc -- Ignore unavailable to you. Want to Upgrade?

To: grayhairs who wrote (6991)	3/21/2001 11:21:20 PM
From: john.d	Respond to of 14101

Mark, here you go, another article on the failure of existing AIDS treatment. The completion of the WF10 phaseII trials are very timely given that most people are now coming to understand the limitations/failure of existing AIDS treatments. John archives.theglobeandmail.com Scientists to study why AIDS drugs fail ANDRÉ PICARD PUBLIC HEALTH REPORTER Wednesday, March 21, 2001 Western researchers are scrambling to determine why drug cocktails are failing for up to half of patients with HIV-AIDS. "The latest AIDS drugs have been a quantum leap forward, but regrettably many people are starting to lose the benefit of these drugs," said Dr. Alan Berstein, president of the Canadian Institutes of Health Research. He said there is an urgent need to "address the increasingly pressing question of how to best treat people for whom all our available drug cocktails have failed." Today, researchers will unveil plans for a massive international study to do so. The four-year, $15.3-million (U.S.) project is a collaboration between the CIHR, the U.S. Department of Veterans Affairs, and the Medical Research Council of the United Kingdom. The so-called Optima (options in management with antiretrovirals) study is the first under an unprecedented, three-country research initiative, which has been likened to a scientific free-trade pact. In particular, researchers will examine the benefits of drug holidays -- suspending antiretroviral drug treatment for three months to allow patients to recover from side effects, and which may leave them more susceptible to renewed attack. They will also evaluate whether existing drugs can be used more effectively in new combinations, and the cost-effectiveness of drug cocktails. In 1996, the medical world was rocked by research indicating drug cocktails could probably eradicate HIV from a person's body within three years. Today, there is a realization that, even at undetectable levels, HIV can hide in reservoirs. Further, the most potent antiretroviral drugs -- even in combinations of up to five drugs -- cannot entirely prevent the wily AIDS virus from reproducing. So, while drug cocktails have cut the death rate by almost 70 per cent in developed countries like Canada, researchers now recognize that they will have to be taken over the long term, and that has important implications because so many of the drugs have serious side effects. The drug cocktails require adherence to a strict schedule, which explains, in large part, the high failure rate. An estimated 50,000 Canadians are living with HIV-AIDS, a fraction of the 34 million people worldwide who are infected. The Optima study will be conducted at 22 hospitals in Canada, 25 in Britain and 30 in the United States.

To: grayhairs who wrote (6991)	3/22/2001 9:28:51 AM
From: Cal Gary	Respond to of 14101

Hi Grayhairs but I'm very bashful yah, LOL. Good to see you in this neck of the woods. Actually the bio business is not that different than in the patch. For example: prospects = clinicals on ideas siesmic = phase I & II drilling claim = phase III spud = full enrollment spuding in several locations = US, Cda, EU, Asia total depth = way past that in UK, rumors of TD in Cdn and US casing = UK deal with Provalis perf = what's going to happen next week, waiting to see what flows out of what holes tight hole = seems perpetual with DMX silence!! pipeline = the vehicle to ship product from our plant to UK market bank = same place where revenue is stored There, you should have much to contribute. Well I'm done killing time and burning bandwidth. Have a great day!!