To: George Dawson who wrote (3212 ) 5/31/2001 7:14:32 AM From: J Fieb Respond to of 4808 More proteomic data.... IBM, MDS team up on free biotech research database By Ian Karleff TORONTO, May 30 (Reuters) - International Business Machines Corp. (NYSE:IBM - news) and Canada's MDS Proteomics (Toronto:MDS.TO - news) said on Wednesday they had created a public database of proteomics research aimed at taming the massive amount of data needed to discover how proteins cause disease. ADVERTISEMENT The new database was created in conjunction with government agencies from North America and Europe. It will provide researchers with a free, centralized repository of proteomics research, outside the growing number of fee-for-service databases operated by the private sector, such as Celera Genomics Group (NYSE:CRA - news) and Myriad Genetics Inc. (NasdaqNM:MYGN - news) -- backed by Hitachi Ltd. and Oracle Corp. (NasdaqNM:ORCL - news). Proteomics is the study of the complex interactions between proteins in a cell and how these chemical reactions form healthy or diseased cells. It has become a major area of focus since last summer's mapping of the human genome. ``We are still at the very early stages of a profound health revolution that started with genomics and now proteomics. We will soon face a coherent and intellectually satisfying look at the determinants of human health,'' said Alan Bernstein, president of the Canadian Institutes of Health Research, and sponsor of the public database. As researchers around the world work feverishly to understand how proteins interact, reams of data are being produced in varying formats and stored on unconnected databases. It is hoped the Biomolecular Interaction Network Database (BIND), that will be managed by a non-profit company called BluePrint Worldwide Inc., will give researchers a central point of access to the growing volumes of data. ``The biggest problem for the life sciences industry right now is the volume and pace of data being generated. We are drowning in data,'' said IBM's vice-president of life sciences Caroline Kovac. BACKING FROM PUBLIC AGENCIES Financial backing for the public database is coming from IBM and MDS Proteomics, a division of Canadian life sciences firm MDS Inc., as well as the National Center for Biotechnology Information, the European BioInformatics Institute, the Canadian Institutes of Health Research and the Samuel Lunenfeld Research Institute. ``Without government support, people would have to pay. Furthermore, this database boasts two other ingredients: critical mass and accessibility,'' said BluePrint managing director Francis Ouellette. Kovac said there are currently over 1,000 public data sources and more than a hundred times that many inside the walls of companies around the world, with much of the data residing in incompatible formats. BIND will annotate over 50 years of literature, which includes about 200,000 scientific papers, and will build on the National Center for Biotechnology Information's GenBank. Ouellette said that while information found in the publicly accessible GenBank are necessary ingredients, BluePrint will provide the recipe to give the ingredients a role in curing disease. An huge amount of computing power is required to crunch proteomics data, as evidenced by the fact that the world's largest commercially operated super-computer is now owned by a biotechnology firm, said IBM's Kovac. ``Biology is driving super-computing like it never did before. Physics always used to be the big driver, but that is not true any more. We started to see that at the beginning of 2000,'' she added. NuTec, which has inked a partnership arrangement with IBM Life Sciences, operates a super-computer that runs at speeds of 7.5 teraflops -- with one teraflop capable of processing one trillion operations per second. ``If you turn the computers off. You couldn't do any of this stuff,'' added Kovacs. Shares of IBM closed down $2.71 at $112.56 on the New York Stock Exchange in a weak market for technology shares, with the Nasdaq composite Index off 4.4 percent. Shares of MDS dipped 15 Canadian cents to C$22.60 on the Toronto Stock Exchange. ($1 equals $1.54 Canadian)