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Biotech / Medical : Biotech Valuation -- Ignore unavailable to you. Want to Upgrade?

To: IRWIN JAMES FRANKEL who wrote (4448)	8/10/2001 3:48:22 PM
From: Biomaven	Read Replies (1) \| Respond to of 52153

IJ, <<TNF in MS>> I've seen a claim that both Enbrel and Remicade have poor blood brain barrier permeability. Peter

To: IRWIN JAMES FRANKEL who wrote (4448)	8/10/2001 5:32:19 PM
From: scott_jiminez	Read Replies (1) \| Respond to of 52153

<<TNF is a factor in the demyelinization of neurons in MS.>> Embrel is CONTRAINDICATED for MS. Treatment with TNF-antagonists such as anti-TNF antibodies or the TNF-receptor (TNF-r; Embrel is a TNF-r/IgG conjugate) has been associated with the exacerbation of MS. The causal relationship between Enbrel therapy and CNS demyelination remains unclear and no clinical trials have been performed evaluating Enbrel therapy on MS. Physicians are instructed to exercise extreme caution in in using Embrel in MS patients (or in any other preexisting or recent-onset CNS demyelinating disorder). In short, anti-TNF therapy appears to be the last thing you would want to give an MS patient. While logic from the scientific literature would strongly suggest that blocking microglial-derived TNF (a proinflammatory or 'bad' cyctokine in this case) during an exacerbation event in MS should be highly beneficial, the actual clinical experience appears to show just the opposite. Thus we can understand why the virtually impermeable tight junctions of the BBB are there: to keep over-eager neurobiology BT companies - and their all knowing academic consultants - from exposing the brain to countless chemicals decades before they have clue of what the hell they're doing. We have a 0.000000000000000000000000000000000000000000001% understanding of brain function. And that's the grossest example of hubris and exaggeration in the history of mankind. [To Irwin - I just got your private message. Your welcome]