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Biotech / Medical : Regeneron Pharmaceuticals -- Ignore unavailable to you. Want to Upgrade?

To: tuck who wrote (561)	9/16/2001 7:08:04 PM
From: tnsaf	Read Replies (2) \| Respond to of 3557

A fixed format version of the table makes it easier to see what is going on. From this study, 1.0 mcg/kg is better than 2.0 mcg/kg, which will help allay safety concerns. Mean Change from Baseline Weight (Pounds) All Available Data for All Patients AXOKINE Placebo 0.3 mcg/kg 1.0 mcg/kg 2.0 mcg/kg Combined AXOKINE 12 Weeks + 0.2 -3.5 -9.1 -8.0 -6.9 (end of blinded treatment) (n=23) (n=23) (n=26) (n=19) (n=68) 18 Weeks + 2.2 -4.7 -9.6 -7.8 -7.4 (6 weeks off treatment) (n=19) (n=22) (n=25) (n=18) (n=65) 24 weeks + 1.9 -4.8 -9.9 -5.8 -7.1 (12 weeks off treatment) (n=19) (n=18) (n=23) (n=17) (n=58) 36 weeks + 3.8 -4.4 -12.4 -5.4 -7.8 (24 weeks off treatment) (n=16) (n=18) (n=19) (n=12) (n=49) 48 weeks + 3.1 -2.9 -12.4 -3.9 -6.7 (36 weeks off treatment) (n=16) (n=17) (n=17) (n=11) (n=45) Results for just those patients who completed the full 48 weeks in the study are: Mean Change from Baseline Weight (Pounds) Data for Patients Who Completed 48 Weeks of Follow-up AXOKINE Combined Placebo 0.3 mcg/kg 1.0 mcg/kg 2.0 mcg/kg AXOKINE n=16 n=17 n=17 n=11 n=45 12 Weeks + 1.1 -5.0 -10.4 -8.0 -7.8 (end of blinded treatment) 18 Weeks + 3.5 -5.4 -12.0 -9.7 -8.8 (6 weeks off treatment) 24 weeks + 2.7 -5.0 -13.1 -7.7 -8.8 (12 weeks off treatment) 36 weeks +3.8 -4.7 -15.6 -5.4 -8.8 (24 weeks off treatment) 48 weeks +3.1 -2.9 -12.4 -3.9 -6.7 (36 weeks off treatment)