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Biotech / Medical : Regeneron Pharmaceuticals -- Ignore unavailable to you. Want to Upgrade?

To: Miljenko Zuanic who wrote (572)	10/1/2001 11:53:31 PM
From: Miljenko Zuanic	Read Replies (1) \| Respond to of 3558

jci.org J Clin Invest, October 2001, Volume 108, Number 7, 1079-1085 Copyright ©2001 by the American Society for Clinical Investigation -------------------------------------------------------------------------------- Article Central melanocortin receptors regulate insulin action Silvana Obici, Zhaohui Feng, Jianzhen Tan, LiSen Liu, George Karkanias and Luciano Rossetti Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA Address correspondence to: Luciano Rossetti, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. Phone: (718) 430-4118; Fax: (718) 430-8557; E-mail: rossetti@aecom.yu.edu. Received for publication April 9, 2001, and accepted in revised form August 8, 2001. Energy balance and insulin action are tightly coregulated. Leptin regulates energy intake and expenditure partly by modulation of the melanocortin pathway in the hypothalamus. Here we demonstrate potent effects of the melanocortin pathway on insulin action and body distribution of adiposity. Conscious rats received week-long infusions of either a melanocortin receptor agonist, -melanocyte-stimulating hormone (-MSH), or antagonist, SHU9119, in the third cerebral ventricle while food intake was maintained constant in each group. -MSH decreased intra-abdominal fat and markedly enhanced the actions of insulin on both glucose uptake and production, while SHU9119 exerted opposite effects. Our findings elucidate a neuroendocrine network that is likely to play a central role in the coupling of energy intake and insulin action.