To: nigel bates who wrote (1406 ) 10/10/2001 12:20:04 PM From: Skywatcher Respond to of 1477 SUNNYVALE, Calif., Oct 10, 2001 /PRNewswire via COMTEX/ Scios Inc. today announced that the company has launched a firstofitskind nationwide registry to collect and analyze demographic and treatment data about patients hospitalized due to acutely decompensated heart failure. ADHERE, the Acute Decompensated HEart failure national REgistry, is expected to have a unique database of information of tens of thousands of patients gathered from approximately 200 hospitals over the next several years. ADHERE is overseen by an independent scientific advisory committee of nationally recognized heart failure experts. Scios created ADHERE to help clinicians better determine factors associated with improved clinical outcomes in acute decompensated heart failure, the primary cause of more than one million hospital admissions in the U.S. each year. "While acute heart failure is a leading cause of hospitalizations and heart failure is the single largest expense for Medicare, information and evidencebased treatment guidelines have been scarce for this fastgrowing medical condition," said Gregg Fonarow, M.D., Director, AhmansonUCLA Cardiomyopathy Center, University of California, Los Angeles and member of ADHERE's scientific advisory committee. "Current heart failure treatment guidelines are drawn from data on stable outpatients. There simply needs to be more data on patients hospitalized with acute heart failure, why they are admitted to the hospital, and what the optimal treatment strategy is. ADHERE will provide comprehensive demographic and treatment data on a wide range of hospitalized heart failure patients. By tracking how these very sick patients are treated over time, we can use this information to identify optimal treatment strategies for them and develop comprehensive acute heart failure guidelines." Roughly five million Americans suffer from heart failure, with 550,000 new cases diagnosed each year. There are approximately one million hospitalizations each year in the United States attributable specifically to acutely decompensated heart failure, which cost the healthcare system $15 billion annually. Another two million Americans are hospitalized each year with CHF as the secondary diagnosis. In the U.S., heart failure represents the most common cause of hospitalizations for patients over age 65. In ADHERE, acute care hospitals across the United States will contribute data securely while maintaining patient anonymity. Information will be collected on patient demographics, medical history, initial evaluation, hospital treatment and medications, resource utilization, procedures and disposition. ADHERE will assist hospitals with their internal quality improvement efforts by providing customized benchmark reports enabling each hospital to compare characteristics of its patient casemix and its patient evaluation and treatment practices with those of similar groups of hospitals, regionally and nationally. CC