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To: Paul Shread who wrote (21165)10/9/2001 10:30:23 AM
From: Frederick Langford  Respond to of 52237
 
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Myriad Genetics Says It Finds Cancer Drug Target

October 09, 2001 08:50:12 (ET)

SALT LAKE CITY, Oct 9 (Reuters) - Myriad Genetics Inc. (MYGN,Trade) said on Tuesday it has discovered a novel drug target for the treatment of a broad range of cancers and has initiated tests with a series of compounds that selectively kill cancer cells.

Its stock was up sharply in pre-opening trade, indicated with a bid of $42.30 and an asking price of $35.36. The stock closed at $34.78 on Monday.

The anti-cancer target was discovered using Myriad's ProNet proteomics technology to investigate the process leading to normal programmed cell death, Myriad said. Pre-clinical studies have demonstrated strong anti-cancer activity in compounds without harming normal human cell survival, the company said.

Myriad said its researchers found that MPI-176716 induces apoptosis, or cell death, in several cancers, including prostate cancer cells and T cell lymphomas.

"The compounds we are developing against this target show broad anti-cancer activity," Myriad President Dr. Adrian Hobden said in a statement.

Fred