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To: jef saunders who wrote (7860)	10/16/2001 11:11:40 PM
From: Montana Wildhack	Read Replies (1) \| Respond to of 14101

Jef, I'm not sure that's bad for Pennsaid if they spend a lot of money raising awareness of non-systemic delivery and the dangers of using systemic solutions to local problems. It sounds as though this would target Celebrex and Vioxx as being the wrong answers. It will be interesting to read what this is about since there's nothing sophisticated enough to travel throughout the body not using the blood stream. And if its travelling through the blood stream, release an ingredient locally without dispersing throughout other parts of the blood stream. I'm also not aware of anything that can carry on board a process that can measure variation from a normal condition or target only a pre-set condition, although biological machrophages come to mind. I have read of advances in nanotechnology that can do precisely this. That is execute an action by actively searching for a pre-set condition trigger. This could be really interesting. Wolf

To: jef saunders who wrote (7860)	10/16/2001 11:22:02 PM
From: shakedown	Respond to of 14101

Jef, I've been searching for "smart drugs" on the web since you posted. Wtih the exception of Nootropic, the references I found to "smart drugs" tend to deal with cell specific delivery (i.e. targets infected cells and leaves normal cells alone), and all the research I have seen tends to target cancers. Its to early to tell though, we'll have to wait and see what they (whoever they are) come out with. I wonder if Dimethaid could ride the coattails of the "smart drugs" concept if the idea get popular? Warren