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Biotech / Medical : Cadus Pharmaceutical Corp. (KDUS) -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (597)	10/20/2001 8:39:15 PM
From: scaram(o)uche	Read Replies (1) \| Respond to of 1833

Here's the abstract from WO0171350............. Methods of registering trans-membrane electric potentials Patent Number: US6287758 Publication date: 2001-09-11 Inventor(s): KALER GREGORY (US); OKUN ALEX (US); OKUN ILYA (US) Applicant(s):: AXIOM BIOTECHNOLOGIES INC (US) Requested Patent: WO0171350 Abstract Sensitive methods for identifying compounds having biological activity comprising combining living cells with two fluorescent membrane permeable ionic dyes having the same charge sign, the first of which has an emission spectrum which overlaps the excitation spectrum of the second fluorescent membrane penetrative dye. The fluorescence is then induced by illuminating the dyes at a wavelength corresponding to the excitation spectrum of the first fluorescent dye and emission is then registered at a wavelength corresponding to the emission spectrum of the second fluorescent dye (FRET). The change in the FRET is indicative of a modulation of cell membrane potential by the biologically active compounds