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Biotech / Medical : HuMAB companies -- Ignore unavailable to you. Want to Upgrade?

To: Gary Mohilner who wrote (252)	11/8/2001 3:03:06 PM
From: scaram(o)uche	Respond to of 1022

>> are far more powerful << That's irritating as hell coming from an IMGN supporter, as -- in the old days of IMGN -- a single ricin A molecule kills. I share your optimism............ I'm a big believer in the advances that have been made, particularly on the targeting end. Your statement was flat out wrong, however, and I merely pointed to such. In spirit, I don't disagree with you. In ten years, your vision made be reflected in the markets. I tend to believe that we'll have (1) experience with immunogenicity using the new generation of immunotoxins, and (2) small molecule solutions that obviate the need for targeted toxins. >> Ricin was large celled which evoked an immune response. << What you say is, of course, true. Ricin elicited a potent immune response. But, (1) small chemicals can also elicit a strong immune response when attached to a protein, and (2) it was IMGN themselves that touted the reduced immunogenicity of "blocked" ricin. Thus far, from IMGN's data, it appears that DM1 conjugates may not elicit a strong immune response. This is a very good thing. All of the old crap that they denied is being recycled as their reason to exist. Ticks me off. We are both impressed with advances at IMGN. I consider them to be incremental apart from the targeting elements, while you seem to assign "miracle" status. We are both pulling for the company, wishing them success. Good luck! Rick