To: SIer formerly known as Joe B. who wrote (348 ) 12/3/2001 6:28:19 PM From: Snowshoe Respond to of 2067 Fats From Veggie Diet Slow Cancer in Micedailynews.yahoo.com Monday December 3 6:06 PM ET NEW YORK (Reuters Health) - Plant-based fats called phytosterols may slow the growth of prostate cancer cells, research in mice suggests. Phytosterols are found in unrefined vegetable oils, nuts and legumes. Prostate cancer (news - web sites) is less common among Asian males compared with men in Western nations, which suggests diet plays a role in the disease, according to Dr. Atif B. Awad and colleagues at the State University of New York at Buffalo. One of the chief dietary differences between these groups is that Asian men consume a higher amount of phytosterols, while the Western diet is heavy in cholesterol, an animal-based fat. To look at the relationship between dietary fats and prostate cancer, the researchers fed one group of mice a diet high in phytosterols and another group a cholesterol-rich diet. Both groups of mice had been inoculated with human prostate cancer cells. After 8 weeks, prostate cancer tumors in mice fed the phytosterol-rich diet were 40% to 43% smaller than those in animals fed the cholesterol diet, the investigators found. In a separate experiment, the scientists examined the effects of two types of phytosterols on prostate cancer cells in the test tube. When added to cell cultures, these chemicals--beta-sitosterol and campesterol--were shown to inhibit prostate cancer cell growth 70% and 14%, respectively. In contrast, when cholesterol was added to the cell cultures, it increased the growth of the cancer cells by as much as 18%, according to the researchers. The study, which was funded by the Peanut Institute, appears in the December issue of the European Journal of Cancer Prevention. ``These studies demonstrated for the first time that (plant) chemicals that exist naturally in our diet can protect against prostate cancer by inhibiting the growth of the human tumor and its spread in the host's tissues, both in animals and the laboratory,'' Awad said in a statement released by the university. Prostate cancer is the most common cancer among American men. Approximately 200,000 new cases are diagnosed every year and there are roughly 31,000 deaths from the disease annually. SOURCE: European Journal of Cancer Prevention 2001 December.