To: nigel bates who wrote (910 ) 1/22/2002 7:24:43 PM From: software salesperson Respond to of 3044 1/22/02 conference call notes 1. 2002 guidance 3-4 nmes in clinic, followed by 5 + in 2005 and thereafter integrilin growth 30% to 300m; mlnm gets 1/2 250m alliance revenue r&d 500 m nol 175-200 m cash 1.7 b + 250 m debt year-end 2. key 2001 accomplishments campath, mln341,mln02,mln977, 10 in clinic + 1 IND filed, 13 preclinical candidates, genomically derived mln4760, abbott, structural genomics,pharsight, 2000 druggable targets, >75 hts, in-licensing of 591, gcc, 576 3. 2002 goals build sustainable pipeline (i) 30% Integrilin increase + new indications (ii) mln341- - multiple myeloma + solid tumor in combination data 1st ½ (iii) 3-4 nmes in clinic (iv) > 75 hts (v) r&d 500 m personalized medicine and productivity- - pharmacogenomics in 6 clinical programs breakeven 2004 m&a and transforming alliances strong balance sheet 4. q&a (i) status of mln 341? - - 400-600 patients in p 3 multiple myeloma; data on mm and solid tumors in may at asco (ii) integrilin market share? - - now into mid 50%; market share data at aac meeting in march (iii) mln02 status?- -data later this year (iv) why increase in g&a ? - - building commercial capability (v) when receive campath revenues? - - 4 q each year (vi) affx collaboration?- - replacing internal platform for gene to patient with affx platform (vii) ’04 breakeven achievable? - - integrilin growth, possible 341 revenue, likely late stage products or products on the market m&a in oncology and cardio areas (viii) which are the 3-4 likeliest nmes? - - no direct answer; across entire portfolio (ix) rtk program?- - both corr and internal; ct53518 will enter clinic shortly; ct53608 for glioblastoma; large focus across all franchise areas (x) oral gp 11b-111a inhibitor status? - - unclear; waiting to observe competitive trial results; not a focus area (xi) mln977 status? - - has oral program; developing inhaled program for asthma (xii) acquire company vs. products? - - no direct answer (xiii) cardio trials are more expensive- is r&d estimate realistic?- - no answer. technical glitch ended the call prematurely 5. impression some focus on short term expenses as well as longer-term strategy. cardio seems like a good move. no real surprises sales