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Biotech / Medical : T/FIF, a New Plateau -- Ignore unavailable to you. Want to Upgrade?


To: nigel bates who wrote (884)2/5/2002 11:52:21 AM
From: Icebrg  Read Replies (1) | Respond to of 2243
 
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Curis (CRIS). (This might have been the last J/V Elan entered into).

CAMBRIDGE, Mass., Jul 18, 2001 (BW HealthWire) -- Curis, Inc.
(NASDAQ: CRIS) today announced that it has formed a joint venture with Elan Corporation, Plc ("Elan") that is committed to the research and development of molecules that stimulate the hedgehog (Hh) signaling pathway. This pathway had previously been shown to play a role in the development of the central and peripheral nervous systems. Curis scientists and collaborators have shown that in the adult, hedgehog is responsible for inducing the repair and regeneration of nerve tissues following injury, trauma or disease. The business venture will focus upon the development of therapeutics targeting a number of neurological disorders. In addition to providing clinical expertise and support for the program, Elan will grant the business venture a non-exclusive license to an important animal model, a mouse strain that develops many of the features of human neurodegenerative diseases.

Under the terms of the licensing agreement, the two companies will each contribute intellectual property to the joint venture. Curis initially will be the majority owner of the joint venture.

"Our scientists have found that stimulating the Hh pathway can have profound and unique effects on cells in the nervous system undergoing degeneration in different diseases, including Diabetic Neuropathy and Parkinson's Disease," stated Dr. Lee Rubin, Ph.D., Senior Vice-President of Research and Chief Scientific Officer of Curis. "We have discovered agents, both protein and small molecules, that potently activate this pathway. We are extremely excited to be working with Elan, a company experienced in neurological disorders, to bring these molecules to the clinic."

Ivan Lieberburg, Ph.D., M.D., Elan's Chief Scientific and Medical Officer stated that, "Elan's partnering strategy gives us the opportunity to leverage very important technology with leaders in their respective fields. I am particularly excited about entering into this important collaboration with Curis. Curis is clearly the world leader in Hedgehog technology, and there is now growing evidence that Hedgehog agonists could have broad reaching applications in a variety of neurological disorders that are extremely important to Elan, including Parkinson's disease, neuropathy, pain, multiple sclerosis and Alzheimer's disease."

"The business venture with Elan demonstrates the value of Curis' strong position in the exploitation of developmental pathways in tissue regeneration," said Dr. Doros Platika, M.D., President and Chief Executive Officer of Curis. "We have identified growth factors and small molecules that have broad applications in many disease areas. This joint venture structure allows Curis to secure the resources for the development of its extensive pipeline while at the same time allowing it to retain a significant portion of the value creation."



To: nigel bates who wrote (884)2/5/2002 12:54:20 PM
From: Icebrg  Respond to of 2243
 
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DOR BioPharma (DOR)

In 1998 Endorex formed two drug delivery joint ventures with Elan Corporation, plc ("Elan"), one of the world's leading drug delivery companies. The purpose of the first joint venture, InnoVaccines Corporation ("InnoVaccines"), is to research, develop and commercialize novel delivery systems for the human and veterinary vaccine markets.

The second joint venture, Endorex Newco, Ltd. ("Newco"), focuses on the utilization of the MEDIPAD(R) microinfusion pump, developed by Elan, to deliver iron chelators for the treatment of a series of genetic blood disorders known as iron overload disorders.



To: nigel bates who wrote (884)2/5/2002 12:57:19 PM
From: Icebrg  Read Replies (1) | Respond to of 2243
 
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ImaRx Therapeutics

ImaRx Therapeutics, Inc. has signed an agreement with Elan Corporation, plc to form a research joint venture to develop and commercialise HydroPlex drug delivery technology for an oncology product.

As part of the agreement, Elan has made an equity investment in ImaRx and provided a credit facility to facilitate funding of the joint venture. ImaRx initially will be the majority owner of the joint venture.

ImaRx's HydroPlex drug delivery system wraps non-water soluble drugs by polymer strands, making the drugs more water soluble, easier to administer and less toxic. ImaRx also has developed energy activated delivery systems uses ultrasound to help release drug payloads from ImaRx's patented microscopic 'smart bubbles' precisely to the site in the body where the drugs are needed. The ImaRx team has a decade-long successful history in the biotechnology field and the company is transitioning from R&D to the development of proprietary production. The joint venture collaboration with Elan will speed the development of work already underway at ImaRx.

Evan Unger, MD, chairman and CEO of ImaRx, said, "This long-term joint venture brings together ImaRx, an acknowledged leader in drug delivery technology and in energy activated delivery systems, and Elan, the industry leader in oral drug delivery technology, with the shared goal of accelerating the development and commercialisation of the ImaRx HydroPlex technology in the field of oncology. With Elan, we now have the technical and financial resources to further advance the development of delivery systems that will revolutionize the way certain diseases are treated."

Dr. Larry Sternson, President of Elan Pharmaceutical Technologies, said, "We are pleased with the opportunity to invest in, and collaborate with, ImaRx. We look forward to working with a highly innovative company like ImaRx that has a leading position in energy-activated and passive drug delivery systems. This collaboration is consistent with Elan's long-term strategy of building multiple alliances with strong emerging technology companies."

ImaRx Therapeutics, Inc. is a privately held biotechnology company organized in January 2000 to apply the tools of biotechnology to the development of sophisticated proprietary drug delivery systems and gene therapy technologies.



To: nigel bates who wrote (884)2/5/2002 1:09:33 PM
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GlycoGenesys (GLGS) previously SafeSciences

BOSTON, July 11 /PRNewswire/ -- SafeScience, Inc., (Nasdaq: SAFS), announced today it closed the transactions with respect to the definitive documents relating to the previously disclosed business venture with Elan Corporation, plc ("Elan"), a worldwide bio-pharmaceutical company headquartered in Dublin, Ireland. The business venture has been formed to further advance GBC-590, SafeScience's lead drug candidate in the field of oncology now in Phase II clinical trials for colorectal and pancreatic cancers.

SafeScience

SafeScience develops and licenses pharmaceutical and agricultural products. The Company's human therapeutic products include GBC-590, a unique compound to treat cancer, which is in Phase II human clinical trials.


The agreement with Elan is as can be expected somewhat convoluted.

On June 22, 2001, SafeScience, Inc. ("SafeScience") entered into a definitive stock purchase agreement with Elan International Services, Ltd. and Elan Corporation, plc. (together "Elan") for the sale of certain securities of SafeScience to Elan International Service, Ltd. and on June 29, 2001 entered into definitive joint venture agreements with Elan to form a joint venture to further advance GBC-590, SafeScience's lead drug candidate, which is now in Phase II clinical trials for colorectal and pancreatic cancer. The transactions with Elan are scheduled to close on or about July 10, 2001.

Elan will invest $5,000,000 for use by SafeScience for general corporate purposes and $12,015,000 for use by SafeScience to purchase its equity investment in the joint venture. The $5,000,000 investment will be in the form of 2,700,000 shares of SafeScience common stock, 1,116.79 shares of SafeScience Series C fixed-price, non-voting, non-dividend bearing preferred stock, convertible into 1,116,790 shares of common stock after two years and a warrant to purchase 381,679 shares of SafeScience common stock exercisable for a period of five years at an exercise price of $2.43 per share. The $12,015,000 investment by Elan will be in the form of SafeScience Series A preferred stock, a fixed-price convertible, exchangeable non-voting instrument bearing a 7% dividend payable-in-kind. The Series A preferred stock, at Elan's election, is (i) convertible into SafeScience common stock or (ii) exchangeable into 30.1% additional equity in the joint venture which will be transferred from the equity initially issued to SafeScience. The Series A preferred stock is redeemable at the end of 6 years by SafeScience if it has not been previously converted or exchanged by Elan, at SafeScience's election, for cash or SafeScience common stock.

SafeScience will purchase 100% of the common stock of the joint venture for $7.5 million and 60.2% of the joint venture's convertible preferred stock for $4,515,000 (totaling 80.1% of the fully-diluted shares in the joint venture) and Elan will purchase 39.8% of the joint venture's convertible preferred stock (or 19.9% of the fully-diluted shares in the joint venture) for $2,985,000. If Elan were to exchange its SafeScience Series A convertible exchangeable preferred stock for the convertible preferred stock of the joint venture held by SafeScience, Elan would own 50% of the fully-diluted equity interest in the joint venture.

SafeScience will sublicense to the joint venture its intellectual property related to GBC-590 for use in the field of oncology. Elan will license proprietary oral drug delivery technology to the joint venture in consideration of $15 million to develop an oral formulation of GBC-590.

SafeScience and Elan will be obligated to fund the joint venture's research and development according to their respective equity holdings in the joint venture. Based on current equity ownership in the joint venture, Elan will provide the joint venture with up to $2,388,000 and will provide SafeScience with access to a funding facility of up to $9,612,000 to fund SafeScience's portion of the research and development funding. The proceeds of the facility are restricted to the funding of SafeScience's portion of the joint venture's costs and will be available to SafeScience through the purchase by Elan of SafeScience's Series B Preferred Stock, a fixed-priced convertible instrument. The Series B Preferred Stock will be non-voting, bear a 7% dividend payable-in- kind and be convertible into SafeScience common stock.

Although the transaction with Elan could be deemed to require shareholder approval under Nasdaq rules, Nasdaq rules provide an exemption from shareholder approval requirements where the delay in securing shareholder approval would seriously jeopardize the financial viability of a company. Having reviewed SafeScience's financial condition and the time necessary to procure shareholder approval, the Audit Committee of SafeScience's Board of Directors has approved SafeScience's reliance upon this exemption. Nasdaq has determined that an exception from the shareholder approval requirement is warranted, therefore SafeScience will not be seeking shareholder approval for the transaction with Elan.

SafeScience will pay certain brokers and advisors at closing an aggregate of $450,000 in cash and warrants to purchase 200,000 shares of common stock at an exercise price of 110% of the closing price of SafeScience's common stock on the date the transaction is closed.



To: nigel bates who wrote (884)2/5/2002 1:19:15 PM
From: Icebrg  Respond to of 2243
 
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Acorda. Dr. Tracy can provide more details on the status of this project, as it was covered in the recent issue of NeuroInvestment.

ACORDA THERAPEUTICS AND ELAN CORPORATION FORM JOINT VENTURE TO DEVELOP FAMPRIDINE FOR TREATMENT OF MULTIPLE SCLEROSIS

New York, NY, July 16, 1998 - Acorda Therapeutics, Inc. announced today that Acorda and Elan Corporation plc (NYSE:ELN) have formed a joint venture to develop Elan’s proprietary, oral, sustained-release formulation of fampridine for treatment multiple sclerosis (MS). Acorda is the majority owner of the joint venture.

Fampridine is the generic name of 4-aminopyridine ("4-AP"), a compound which increases the ability of demyelinated nerve processes ("axons") to conduct electrical impulses. In initial human clinical trials of fampridine, scientists have reported encouraging results in enhancing neurological function both in people with MS and spinal cord injury ("SCI"). Under the agreement announced today, Elan has granted to the joint venture exclusive, worldwide rights to develop and market Elan’s proprietary formulation of fampridine for multiple sclerosis. Acorda will conduct MS clinical development of the product on behalf of the joint venture, and will continue independently to develop fampridine for SCI, under a previously announced agreement with Elan.

Fampridine acts by blocking specialized potassium channels on nerve cells and axons. These channels become exposed when the insulating myelin sheath around the axons is damaged, as in trauma or disease. The exposed potassium channels permit current to "leak." out of the axon, short-circuiting normal conduction. By blocking these channels, fampridine restores the ability of the axon to conduct. This effect appears to persist as long as fampridine is present, so that the drug, if successfully developed, would need to be taken chronically to maintain an effect.

Commenting on the significance of the deal, Ron Cohen, M.D., President and CEO of Acorda, said: "Fampridine is the first medical therapy to show potential for improving neurological function in people with demyelinating conditions such as MS and spinal cord injury. Under Acorda’s original collaboration with Elan, the company expects to complete a Phase II clinical trial of fampridine in SCI by the end of this summer. Our new agreement with Elan expands the scope of Acorda’s development program to include a second promising disease target for fampridine."

Michael Sember, Executive Vice President of of Business Development at Elan and a Director of Acorda, said: "Elan and Acorda have collaborated successfully over the past year and a half to advance the clinical development of fampridine for SCI. We are pleased to be building on this relationship with our new joint venture for MS."

Acorda is a privately held biotechnology company developing therapies to preserve and restore neurological function in people with SCI and other neurological conditions, including MS. The Company, which was incorporated in 1995, also is developing proprietary technologies for neuroprotection, and for remyelination and regeneration of nerve tissues.



To: nigel bates who wrote (884)2/5/2002 1:26:54 PM
From: Icebrg  Respond to of 2243
 
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Inex Pharmaceuticals (TSE:IEX)

Inex Pharmaceuticals Forms Joint Venture with Elan Corporation to Develop and Commercialize Onco TCS

For immediate release: Apr 30, 2001

VANCOUVER - Inex Pharmaceuticals Corporation ("INEX"; TSE: IEX) announced today it has formed a joint venture with Elan Corporation, plc ("Elan"; NYSE: ELN) for the development and commercialization of INEX's lead product, Onco TCS, now being evaluated in human clinical trials as a treatment for a number of cancers. INEX and Elan have both contributed assets to the joint venture including worldwide rights to Onco TCS and complementary intellectual property.

David Main, INEX's President and CEO, said INEX could receive up to Cdn$60 million (US$39 million) in funding related to the joint venture and, completed today, an upfront Cdn$7.5 million purchase of INEX common shares. INEX and Elan will share profits from the product's commercialization.

"This agreement meets our objectives for a partnership for Onco TCS," Main said. "It brings considerable funds to complete and expand the development of Onco TCS and INEX retains a profit sharing arrangement with an international pharmaceutical company committed to oncology."

"During our partnering process, Elan emerged as the preferred partner as they provide the added benefits of access to complementary intellectual property and expertise in the development, manufacturing and marketing of liposomal and other drug delivery products."

Dr. Ivan Lieberburg, Chief Medical and Scientific Officer of Elan Corporation plc, said "We are pleased to join with INEX in this joint venture as they have demonstrated that their advances with TCS delivery technology provides a strong competitive advantage for Onco TCS. Onco TCS has the potential to become an important therapy for a number of cancers and complements other cancer drugs in our product portfolio including MyocetTM and AbelcetTM."

MyocetTM and AbelcetTM are approved liposomal formulations of drugs for the treatment and management of cancer patients.

About Onco TCS
INEX's lead product, Onco TCS, is a proprietary drug composed of the widely used off-patent cancer drug vincristine encapsulated in the company's TCS (liposomal) drug delivery technology. The TCS technology provides prolonged blood circulation, tumor accumulation and extended drug release at the cancer site. These characteristics are designed to increase the effectiveness and reduce the side effects of the encapsulated drug.

Onco TCS is in a pivotal Phase II/III clinical trial as a treatment for relapsed aggressive non-Hodgkin's lymphoma. The trial is expected to provide sufficient data to seek marketing approval, with a regulatory filing in late 2002 or early 2003. Onco TCS is also in Phase II clinical trials as a treatment for small cell lung cancer, relapsed solid tumours and leukemia in children and adolescents and first-line treatment of non-Hodgkin's lymphoma.

In 2000, Elan acquired The Liposome Company ("TLC"), of Princeton, NJ, a biotechnology company dedicated to the development and commercialization of proprietary lipid and liposome-based pharmaceuticals. The contribution by Elan to the joint venture of certain TLC intellectual property will strengthen the overall intellectual property position of Onco TCS and will eliminate the need to pay certain third-party royalties INEX had previously anticipated.



To: nigel bates who wrote (884)2/5/2002 1:29:16 PM
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Beyond Genomics Forms Alzheimer’s Disease Joint Venture with Elan Corporation

Strategic Alliance First To Apply Systems Biology To Identify Biomarkers And Drug Targets


Cambridge, MA–May 15, 2001 – Beyond Genomics, Inc. today announced that it has formed a joint venture with Elan Corporation, plc (“Elan”) to apply novel systems biology technologies in the conduct of Alzheimer’s disease research. The planned two-year program will seek to identify novel biomarkers and drug targets useful for the diagnosis and treatment of Alzheimer’s disease. Coincident with the establishment of the joint venture, Elan made a $5.0 million equity investment in Beyond Genomics. Other financial details were not disclosed.

“We are pleased to be working with Elan, a world leader in the field of Alzheimer’s disease therapeutics and diagnostics,” said N. Stephen Ober, MD, President of Beyond Genomics. “In addition to providing clinical expertise and support for the program, Elan will grant the joint venture a non-exclusive license to an important animal model, a mouse strain which develops many of the features of the human disease,” Ober added. “The joint venture with Elan is our first corporate partnership, and a significant achievement for our company,” added Noubar B. Afeyan, Ph.D., Chairman of Beyond Genomics and CEO of NewcoGen Group

“Beyond Genomics’ system biology platform has the potential to identify new proteins involved in Alzheimer’s disease which could have important implications for better diagnosing and treating this devastating disease,” said Dale Schenk, Ph.D., Senior Vice President of Discovery Research for Elan Pharmaceuticals.

Alzheimer’s disease is characterized by progressive degeneration of the brain, resulting in cognition impairment and memory loss. The disease currently affects about 4 million people in the US. This number is expected to grow as the population ages, reaching 5.5 million by 2010. Alzheimer’s disease is difficult to diagnose and treatment options are limited. A recent study by the Alzheimer’s Association (www.alz.org ) predicts that Medicare costs for treating people with Alzheimer’s disease will rise from about $32 billion last year to over $49 billion by 2010.

A first mover in the field of systems biology, Beyond Genomics has pioneered an approach to rapidly analyze clinically relevant samples and integrate data at the gene, protein, and metabolite levels. This systems biology approach goes beyond genomics to provide new insights into the molecular mechanisms of health and disease. In collaboration with strategic partners, Beyond Genomics leverages its technology platform across a portfolio of applications in drug discovery, product development and diagnostics The Company was co-founded by NewcoGen, a unit of NewcoGen Group, and has received $5.5 million of Series A funding from NewcoFunds and OneLiberty Ventures. For more information visit www.beyondgenomics.com .



To: nigel bates who wrote (884)2/5/2002 1:31:11 PM
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ATHERSYS ANNOUNCES FORMATION OF JOINT VENTURE WITH ELAN

-- Alliance Will Commercialize Therapeutic Protein for Treatment of AIDS-associated muscle wasting --

Cleveland, February 15, 2000 - Athersys Inc., today announced that it has formed a joint venture with Elan Corporation, plc, to develop and commercialize an undisclosed therapeutic protein. The joint venture will combine Athersys' RAGE (Random Activation of Gene Expression) ™ technology with an Elan drug delivery system. Under the terms of the agreement, Elan has made a significant equity investment in Athersys; no further financial details were disclosed.

This joint venture takes advantage of the Athersys RAGE-KTP™ technology, a novel protein expression technology that enables commercial scale production of therapeutic proteins in human cell lines by activating high level expression of the endogenous gene that encodes the protein of interest. Athersys is currently developing several proteins produced using the RAGE-KTP approach.

"This joint venture combines Elan's experience with drug delivery systems with the RAGE technology's protein production capabilities," said Dr. Gil Van Bokkelen, chairman, president and chief executive officer of Athersys.

The RAGE technology enables the creation of production cell lines without the use of standard recombinant DNA methodologies to clone and isolate a gene in order to achieve high level protein expression. In contrast to alternative technologies, such as cDNA expression cloning, RAGE does not require advance knowledge of gene sequence, structure, or typical expression pattern in order to activate expression of a given gene. Rather, the RAGE approach is used to randomly activate genes throughout the genome, ultimately resulting in the creation of comprehensive, genome-wide protein expression libraries. In this way, we believe the RAGE technology can be used to activate and express protein from virtually any gene in the human genome, irrespective of its typical expression pattern in the human body. High-throughput screening methods are then applied to rapidly detect the cell expressing the protein of interest, which are then expanded in cell culture to generate a production cell line.

Athersys is a functional genomics and biopharmaceutical company engaged in the development and application of novel research tools and therapeutic products. The Company's RAGE (Random Activation of Gene Expression)™ technology platform is a novel gene expression system that enables the Company to rapidly survey the entire human genome for proteins with a specific biological function and to quickly and accurately correlate protein function with gene structure. Athersys believes RAGE has powerful applications in functional genomics, generation of validated drug targets, development of protein therapeutics and gene discovery. The Company's SMC (Synthetic Microchromosome) technology platform enables the Company to create synthetic human chromosomes, which are being developed as a novel approach to gene therapy. Athersys is establishing a broad portfolio of proprietary technologies that positions the Company to develop therapeutic products, both internally and with strategic partners, to treat significant and life-threatening diseases. This press release and further information on Athersys, Inc. can be found on the World Wide Web at: www.Athersys.com.



To: nigel bates who wrote (884)2/5/2002 1:34:03 PM
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Photogen Technologies Forms Joint Venture with Elan Corporation to Advance Comprehensive, Non-Surgical Approach to Detection And Treatment of Cancer in the Lymph Nodes Photochemical Techniques May Offer Non-Invasive Alternative for Detection, Diagnosis and Treatment; Phase II Human Trials Set for Next Year

KNOXVILLE, Tenn., Nov. 2, 1999 -- Photogen Technologies Inc. (OTC BB: PHGN) today announced a joint venture with Elan Corporation, plc ("Elan") to develop and commercialize nanoparticulate diagnostic imaging agents for the detection and treatment of cancer that has spread to patients' lymph nodes.

The goal of the joint venture is to develop a treatment that would more than halve the number of lymph node surgeries by precisely locating the nodes where cancer has spread and at the same time, if necessary, treating the affected lymph nodes in one all-inclusive, non-invasive procedure.

Each company is contributing significant intellectual property and know-how to the venture. Photogen's contribution includes knowledge relatinged to lymphography accessed through recent acquisition and licensing agreements with Alliance Pharmaceuticals and Massachusetts General Hospital (see Photogen press release dated Oct. 26, 1999). Elan, through its drug delivery division Elan Pharmaceutical Technologies, is contributing its NanoCrystal(tm) stabilized nanoparticulate formulation technology to develop formulate the diagnostic imaging agents. Phase II human trials with the venture's lead candidate are expected to begin in 2000. Elan will provide Photogen with a credit facility to fund its share of the development costs of the joint venture. In addition, Elan has purchased $6 million of Photogen's common stock as part of the agreement.

"This corporate venture with Elan in the field of lymphography will enable us to redouble our efforts in bringing to market non-invasive methods for determining how much cancer a patient has and how far it has spread," said John Smolik, president and CEO of the Knoxville, Tenn.-based biotech firm.

"With our approach, we believe we can significantly reduce the number of lymph node surgeries used to determine the spread of cancers, including melanoma and cancers of the breast, prostate, lung, and head and neck."

Eugene Cooper, Executive Vice President Research and Development at Elan Pharmaceutical Technologies added, "Elan's NanoCrystal(tm) technology has significant application in the field of diagnostic imaging. We are delighted to have the opportunity to combine this technology with the know-how and expertise of Photogen, a leader in the emerging field of photodynamic therapy, to help advance the detection and treatment of diseases of the lymph node."



To: nigel bates who wrote (884)2/5/2002 1:55:17 PM
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NewBiotics, Elan Corp. Form Joint Venture To Develop Colon Cancer Treatment

SAN DIEGO, February 6, 2001 - NewBiotics Inc. and Elan Corp., plc (NYSE:ELN), today announced they have formed a joint venture to develop and commercialize NewBiotics' lead compound, NB1011, to treat cancer in the United States, Canada and Europe. The initial focus of NB1011 will be on treating patients with colorectal cancer who have not responded well to standard chemotherapy.

As part of the agreement, Elan has made an equity investment in NewBiotics and gained the opportunity to negotiate commercialization rights to NB1011 for cancer treatment in the United States, Canada and Europe. In addition, the joint venture will receive certain rights to utilize Elan's NanoCrystal™ technology.

"We are enthusiastic about our collaboration with Elan aimed at beginning human clinical trials for NB1011 and future commercialization of this product," said Roger L. Headrick, chief executive officer of NewBiotics. "The technical and financial resources furnished by Elan will greatly expedite the development of our unique and proprietary ECTA technology," added H. Michael Shepard, Ph.D., president and chief scientific officer of NewBiotics.

"This agreement not only reflects our enthusiasm about the potential of NB1011 to become an important part of colon cancer treatment, but also our belief in NewBiotics' approach to target identification and drug discovery," said Ivan M. Lieberburg, M.D., Ph.D., executive vice president, and chief scientific and medical officer at Elan's South San Francisco facility.



To: nigel bates who wrote (884)2/5/2002 1:59:42 PM
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(The year is 2001).

Generex Biotechnology to Form Joint Venture With Elan Corporation

- Joint Venture to Focus on Products to Treat Prostate Cancer, Endometriosis and/or Suppression of Testosterone and Estrogen -

TORONTO, Jan. 4 -- Generex Biotechnology Corporation today announced that it has signed an agreement to form a joint venture with Elan Corporation. The joint venture will pursue the application of certain proprietary drug delivery technologies of Generex and Elan to pharmaceutical products for the treatment of prostate cancer, endometriosis and/or the suppression of testosterone and estrogen. Under the terms of the agreement, Elan will also make an initial $5 million equity investment in Generex. The transaction will close later this month.

The joint venture will have non-exclusive licenses to utilize Generex's proprietary buccal delivery technology and certain of Elan's proprietary drug delivery technologies. Generex and Elan will each contribute to the funding of the joint venture and will each provide clinical development, regulatory, project development and business development guidance to the venture.

"We are extremely pleased to enter into a joint venture relationship with Elan," said Anna Gluskin, President and CEO of Generex. "Elan is a world leader in the area of drug delivery technology. The joint venture will enable Generex to accelerate efforts to develop additional products in fields we consider extremely promising using our proprietary buccal drug delivery system."

Ivan Lieberburg, Elan's Chief Science and Medical Officer, stated, "We believe that the combination of Generex's technologies with Elan's experience and know-how will give rise to a venture with outstanding prospects for successful development results. We believe buccal delivery of large molecule drugs represents a tremendous opportunity as it will, in our opinion, enhance patient compliance and offer less potential side effects than other drug delivery systems."



To: nigel bates who wrote (884)2/5/2002 2:03:06 PM
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Elite Pharmaceuticals Forms Joint Venture With Elan

NORTHVALE, N.J., Sept. 21 /PRNewswire/ -- Elite Pharmaceuticals, Inc. (Amex: ELI - news; OTC Bulletin Board: ELIPZ - news) announced today that it has signed an agreement to form a joint venture with Elan Corporation (NYSE: ELN - news) to develop several pharmaceutical products in areas of strategic interest to Elan. Under the terms of the agreement, the joint venture formed by the companies will license exclusively from the respective companies certain oral drug delivery technologies for development of these products. Elan will also make a $5 million equity investment in Elite.

“We are extremely pleased to have the opportunity to enter a joint venture arrangement with Elan, whose EPT division is the world's leading drug delivery company. The joint venture, when consummated, will enable us to develop several products utilizing resources of each company,” said Dr. Atul Mehta, President and CEO of Elite.

Max Gershenoff of Elan stated, “We are pleased to have formed a joint venture with Elite, which will enable the accelerated development of products which are of strategic interest to Elan.” Both Elan and Elite will continue their own development of products outside the joint venture and both will continue to collaborate with other companies.

Recently, Elite had signed a memorandum of understanding with Inabata to form a joint venture in Japan to license and market Elite products in Japan. Elite will retain control of this joint venture company, when formed, and contribute products and technology whereas Inabata will provide funding and marketing support.

Elite specializes in the development of delayed release, sustained release, release and other controlled release formulations, including taste masking. Elite has been issued several patents including pulse release methylphenidate drugs (U.S. Patent 5,837,284). The latter has been assigned to Celgene who recently licensed it to Novartis.



To: nigel bates who wrote (884)2/5/2002 2:06:55 PM
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ATLANTA, GA. August 16, 2000…..Altea Genomics, Inc. (Altea) announced today that it has entered into an agreement with Elan Corporation, Plc. and certain affiliates forming a joint venture company to develop up to five products utilizing Altea’s non-invasive MicroPor™ technology and Elan’s formulation technology. The primary product focus is DNA vaccines and gene therapy.

Altea’s patented MicroPor™ technology creates microscopic pores in the outermost dead layer of skin cells, opening tiny pathways to the underlying viable tissues. Altea has demonstrated delivery of physiologically-relevant amounts of peptides and proteins in pilot clinical studies with compounds such as insulin and parathyroid hormone (1-34). In addition, Altea has demonstrated delivery of macromolecules up to 2,000,000 daltons. The system enables needleless administration of biotechnology products with delivery profiles that can be tailored as desired for different applications, e.g., a steady infusion of the drug, or a bolus delivery as required. This technology enables convenient, controllable transdermal delivery of these macromolecular drugs, which is not possible with other non-invasive systems. Furthermore, the MicroPor™ system allows delivery of DNA vaccines to the epidermal layer of the skin, in the vicinity of the Langerhans or dendritic cells, which are important for antigen presentation and the immune response.

"We are delighted to have entered into this collaboration with Elan," commented Deborah Eppstein, Ph.D., Altea’s Chairman and Chief Executive Officer. "Elan is a world leader in the development and commercialization of innovative products using novel drug delivery systems. Altea’s technology allows biotechnology drugs, such as DNA vaccines or gene therapy products, to be conveniently delivered to patients without use of a needle or other invasive methods. By teaming with Elan, our new Joint Venture company will be able to leverage Altea’s MicroPor™ technology with the formulation expertise of Elan to efficiently develop these products."

John Devane, Ph.D., Executive Vice President of Research and Development, Elan Pharmaceutical Technologies, said "Elan is very excited to be now working with Altea in the area of enhanced delivery into the skin and to be in a position to advance the delivery, in particular of DNA based therapy, by this novel route of administration".

Under the agreement, the new Joint Venture Company will develop up to five products, focusing on DNA delivery. Products under consideration include DNA vaccines against infectious diseases and cancer, encompassing preventative as well as therapeutic vaccines depending on the application. The new company will seek pharmaceutical partners for certain products, and under some situations, Elan Pharmaceuticals, Inc. may market certain products.

Altea is a member of the privately held family of companies developing the MicroPor™ technology for drug delivery applications, including delivery of vaccines and gene therapy products by Altea Genomics; and delivery of peptides and proteins, as well as small molecules requiring rapid and on-demand onset of action, such as pain medications by Altea Development Corp. The non-invasive monitoring applications of the MicroPor™ technology are licensed to SpectRx, Inc. (NASDAQ: SPRX), who is developing the glucose monitoring products with Abbott Laboratories (NYSE: ABT).



To: nigel bates who wrote (884)2/5/2002 2:10:41 PM
From: Icebrg  Respond to of 2243
 
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ZEALAND PHARMACEUTICALS IN JOINT VENTURE WITH ELAN

Zealand Pharmaceuticals (”Zealand”) has entered into a joint venture agreement with Elan Corporation plc (”Elan”) for the development of a drug for the treatment of Type II Diabetes.

The joint venture will combine Zealand’s proprietary compounds for Type II Diabetes with Elan’s drug delivery technologies. Zealand has obtained promising pre-clinical results, which show a significant reduction in blood glucose in diabetic animals after administration with the Zealand compounds. As part of the joint venture agreement, Elan has made an equity investment in Zealand, and Elan will be represented on the Board of Directors of Zealand.

Eva Steiness, CEO of Zealand: ”We are delighted to have Elan as a partner for our diabetes project and as a shareholder. Elan is a professional partner with a strong record within drug delivery and also pharmaceutical development. We look forward to drawing on Elan’s knowhow, first of all within the area of delivery technology but also within general scientific and commercial areas.”

Zealand is a Danish biotech company founded in October 1998. The aim is to research, develop and obtain market approval for new drugs with significant improvements in the treatment of severe diseases. Zealand focuses on peptide based drugs. The major shareholders are BankInvest, Ikano, LD, Elan Corporation and senior staff of the company. Zealand employs a staff of totally 35 people.



To: nigel bates who wrote (884)2/5/2002 2:16:38 PM
From: Icebrg  Respond to of 2243
 
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2 Feb 2001

Verion, Inc. has entered a joint venture with Elan Pharma International Ltd., an affiliate of Elan Corporation, plc, a world leader in drug delivery systems.

The joint venture, Verion Newco Ltd., will use both companies' patented drug delivery technologies -- Verion's Pressure Pulse Technology (PPT) and Elan's NanoCrystal technology -- to develop new controlled-release drug compounds. Details of the agreement were not disclosed. According to SG Cowen, an industry analyst, sales of drugs using drug delivery technologies are expected to reach $24 billion by 2003.

"We are very pleased to have Elan as a partner," said John Sedor, President and CEO of Verion Inc. "This agreement allows us to capitalize on complementary technologies and expertise, resulting in the accelerated development of major improvements in drug delivery. Our focused efforts with Elan represent a first step toward fully exploiting the broad range of applications we see for PPT within the pharmaceutical industry."

Dr. Larry Sternson, President of Elan Pharmaceutical Technologies, said, "Elan is delighted to be working with Verion on the development, manufacture and eventual commercialisation of controlled-release pharmaceutical products. We believe that our combined technologies will lead to substantially improved dosing, reduced side effects, and enhanced patient compliance."

Verion's technology is unique in the drug delivery industry. Its PPT technology platform functions by applying high pressure to chemical compounds for short periods of time, changing physical characteristics without altering their chemical properties. As a result, PPT improves the design and performance of controlled-release drugs. The technology also improves product stability and protects active ingredients from moisture and other undesirable environmental elements.

Verion is a privately held company that specializes in innovative delivery systems for the pharmaceutical industry. The company seeks to become a leader in the global microencapsulation, drug delivery and oral dosage markets.



To: nigel bates who wrote (884)2/5/2002 2:24:24 PM
From: Icebrg  Respond to of 2243
 
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In December 1999, Elan Corporation plc filed a new drug application (NDA) for ziconotide to receive FDA marketing approval. An approvable letter from the FDA was received by Elan in June 2000. Ziconotide is an w-conopeptide discovered in the University of Utah laboratory of Dr. Olivera. Ziconotide has been developed for the treatment of malignant and neuropathic pain, again employing the Medtronic SynchroMed® infusion system to facilitate intrathecal delivery. In 1998 Elan purchased Neurex Corporation for $740 million in order to acquire the rights to ziconotide.

In January of 2000, Cognetix and Elan teamed up in a joint venture (JV) to develop and commercialize another Cognetix conopeptide, contulakin-G (CGX-1160). CGX-1160 is intended to be developed for the short-term management of post-operative pain.



To: nigel bates who wrote (884)2/5/2002 2:30:48 PM
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Elan/AvMax oral drug delivery deal

Elan and the US company, AvMax, are to collaborate on oral drug delivery using both companies’ technology.

AvMax’s proprietary technology addresses the inherent problems of oral bioavailability of many products such as immunosuppressants, protease inhibitors, anticancer agents and cardiovascular products, the company said. It is based on the inhibition of members of the cytochrome P450 3A sub-family (CYP3A) and P-glycoprotein (P-gp). These two proteins limit drug absorption by reducing the amount of active ingredient which passes through the intestine wall.

The company is developing inhibitors of intestinal metabolism and active efflux, many of which are designated by the US FDA as substances generally recognized as safe (GRAS), such as food flavorings or extracts, for example peppermint oil.

GRAS substances can be incorporated into product formulations with minimal additional toxicology testing, simplifying the regulatory pathway, the company told Scrip. Elan is to take an equity stake in AvMax of slightly less than 20%.

Elan said the venture forms part of a broad series of collaborations it has been setting up and that AvMax’s oral drug delivery technology is complementary to that of NanoSystems, which Elan acquired last year. NanoSystems’ main technology in NanoCrystal, which enhances the delivery of poorly water-soluble drugs.

. . . AvMax

AvMax was formed in 1993. One of its founders is Dr. Leslie Benet, who has conducted pioneering research on the role of P-gp and CYP3A in limiting oral absorption of peptides and peptidomimetics. He is professor and chairman of the department of biopharmaceutical sciences at the University of California, San Francisco.

The company has supported itself financially in recent years by undertaking feasibility projects for pharmaceutical companies. AvMax hopes to secure more deals with companies experiencing difficulties with bioavailability and expects funding from these to support it for the next couple of years.



To: nigel bates who wrote (884)2/5/2002 2:38:05 PM
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MicroDose Reports Success in First Clinical Trial For Inhaled Insulin Using Novel MicroDose Device

Needle-free Alternative for Diabetes Treatment

MONMOUTH JUNCTION, N.J., Dec. 6 /PRNewswire/ -- MicroDose Technologies Inc (``MicroDose''), a leading drug delivery company, announced today the successful completion of a Phase I clinical study evaluating the pulmonary delivery of human insulin, being conducted with joint venture partner, Elan Corporation, plc (``Elan''). This is the first clinical study to evaluate Elan's proprietary dry powder formulations of insulin in combination with MicroDose's novel dry powder inhaler (DPI) and initial results indicate significantly improved bioavailability compared with competitive products currently in development.

This rapid acting insulin product has been developed by QDose, a joint venture company established between Elan and MicroDose, and will be targeted at the treatment of both Type I and II diabetes as a patient-friendly and convenient approach to replacing the subcutaneous insulin injections required to control meal-related glucose levels.

The UK-based study was conducted in 18 healthy male volunteers and was designed to demonstrate the efficiency of delivery of Elan's dry powder insulin from the MicroDose device. Blood levels of insulin and glucose were measured over time following inhalation of either pure insulin or an insulin-trehalose formulation (a formulation designed to allow long term storage at room temperature). Pulmonary delivery was compared with subcutaneous injected insulin, as a control.

Absorption of the inhaled insulin was rapid with a Tmax (time to maximum blood concentration) of 37-39 minutes (depending on the formulation) compared with a Tmax of 102 minutes for the subcutaneous insulin control, providing the opportunity for more rapid and complete control of blood glucose levels at meal times compared with conventional insulin injections. The bioavailability over the initial 3 hours of the inhaled insulin relative to the subcutaneous dose was 23-25% depending on the formulation. These data compare extremely favourably with those of competitor approaches in pulmonary drug delivery.

The MicroDose DPI is an active, multi-unit dose device, which achieves high-efficiency powder dispersion independent of patient inhalation effort and has demonstrated excellent dose reproducibility. It is designed to be a lightweight, low cost, pocket-sized device.

``These Phase I results are extremely encouraging'' said Anand Gumaste, CEO of MicroDose. ``Clearly we are in a highly
competitive field, but the outcome of the study positions us strongly as we seek a development partner and move this product through development.''

For MicroDose, this is the first time that this inhaler device has been tested in clinical trials. ``The results of this pioneering study are very exciting and prove our ability to develop technologies which deliver active molecules to the required sites of action quickly and effectively. The performance levels we have observed demonstrate clear potential to evaluate other bioactive molecules using this device,'' commented Scott Fleming, Vice President, Marketing, MicroDose.

Notes to Editors:
About MicroDose Technologies:
MicroDose Technologies, Inc. is a privately held drug delivery company developing advanced pulmonary, solid oral dosage, and needlefree transdermal products for the pharmaceutical industry. The Microdose dry powder inhaler
(DPI) is a handheld, low cost, breath activated device which makes novel use of piezo electronics to efficiently deliver a broad range of compounds. Such compounds include small and large molecule therapeutics for local and systemic applications. This device is the first totally electronic DPI and represents the next generation in inhaler technology both in performance and ease of use.



To: nigel bates who wrote (884)2/5/2002 2:44:57 PM
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6 Oct 1999

Sheffield Pharmaceuticals, Inc has signed a letter of agreement to enter into a licensing arrangement with Elan Corporation plc for development and commercialization of certain inhaled steroid products for the treatment of respiratory diseases.

Under the terms of the agreement, a joint venture formed by the companies will license certain pulmonary NanoCrystal dispersion technology from Elan Pharmaceutical Technologies, a division of Elan, for development of these products. Sheffield will provide the joint venture with access to certain of its pulmonary delivery systems. Elan will provide funding to Sheffield and the joint venture as part of the agreement.

The venture partners will both provide clinical development, regulatory, project development and business development guidance. The joint venture will develop unique steroid products that utilize Elan's proprietary NanoCrystal dispersion technology. NanoCrystal dispersion technology enables delivery of poorly water-soluble medicines, such as steroids, by transforming these drug compounds into nanometer-sized particles that can be incorporated into traditional dosage forms, such as aerosol formulations.

Thomas M. Fitzgerald, Chairman of Sheffield Pharmaceuticals stated, "This joint venture will allow us to take advantage of a number of untapped opportunities to develop products for the $7 billion worldwide asthma market. The venture will combine Elan's unique and promising nanoparticulate technology with the capabilities of our pulmonary delivery systems."

Eugene R. Cooper, Ph.D., executive vice president research and development of Elan Pharmaceuticals Technologies commented, "This agreement is a testament to the strategic role that drug delivery technology can play in addressing important unmet market needs. Combining our technological capabilities with Sheffield's innovative delivery systems will help achieve our goal of developing and commercializing innovative medicines and ultimately providing relief to millions of patients suffering from respiratory diseases."

Under the terms of the transaction, Sheffield will own 80.1% of the joint venture. Additional financial terms are expected to be disclosed at the time the transaction is finalized, which is expected in the next month.



To: nigel bates who wrote (884)2/5/2002 2:52:54 PM
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TORONTO, March 6, 2000 - Spectral Diagnostics Inc. (TSE: SDI), developer of innovative diagnostic technologies, today reported that it has committed to issue 2,500,000 common shares to Dr. Paul Walker and Dr. Alex Romaschin in exchange for their 27% interest, on a fully diluted basis, in Sepsis Inc., Spectral's joint venture partner in the development of diagnostic tests for infections. Drs. Walker and Romaschin will maintain their senior roles in the direction, development and commercialization of these important diagnostic products.

This transaction has been valued at $5.2 million and is conditional upon the attainment of certain milestones by Sepsis Inc. Spectral will issue to Drs. Walker and Romaschin:

- 1,500,000 common shares upon filing by Sepsis Inc. of the pre-market approval ("PMA") submission to the FDA for a test designed to rule out gram negative infections; and
- 1,000,000 common shares upon receipt of confirmation of approval from the FDA for marketing of the test to rule out gram negative infections.

All common shares issued will be subject to a one-year hold period from the date of issue.

Upon conclusion of all elements of the transaction Spectral will own 86% of Sepsis Inc. on a fully diluted basis and Spectral will have a total of 13,350,841 common shares issued and outstanding. Spectral is also in discussions to acquire the remaining shares of Sepsis Inc. which it does not already own.

Dr. Calvin Stiller, Chairman of Spectral said, "We are very excited about our diagnostic tests for infections. The acquisition of an additional 27% of Sepsis Inc. will benefit the shareholders of Spectral in that the Company is broadening its base of diagnostic tests. A broader product base will open up new growth opportunities."

In 1998, Spectral and Sepsis Inc., entered into an alliance with Elan Corporation, plc ("Elan"). Under the terms of this alliance, Elan acquired an interest in Sepsis Inc. and world-wide marketing rights for diagnostic products for infections in exchange for development funding and certain milestone payments. The milestone payments associated with regulatory filings and approvals of the test in the United States, Europe and Japan to rule out gram negative infections could total up to US $12 million. Under the agreements, Sepsis Inc. retains exclusive manufacturing rights for these products and a significant royalty entitlement based on "in market" sales of the tests. Upon acceptance by the FDA of a PMA for the test to rule out gram negative infections, Sepsis Inc. will receive a milestone payment of US $2.5 million. A further milestone payment of US $1.5 million will be earned upon receipt of FDA regulatory approval for this test. In addition to the development of the test to rule out gram negative infections, early stage development of the gram positive diagnostic test is now underway.

Each year there are an estimated 750,000 cases of septic infection reported in the United States alone. With mortality rates of up to 40%, sepsis represents one of the leading causes of patient death and costs to the health care system. Conventional methods for diagnosing infection include the use of cultures that provide diagnostic information in 24 to 72 hours. Sepsis Inc.'s gram negative test, the first in a family of diagnostic tests, is intended to provide additional diagnostic information to physicians in one hour.



To: nigel bates who wrote (884)2/5/2002 2:59:59 PM
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For Immediate Release 2 July 1999
MEDISYS PLC

("Medisys")

Joint Venture with Elan Corporation plc

Subscription by Elan for 6,072,874 new Medisys Ordinary Shares at 31.25p per share

Highlights

* Joint venture established with Elan to develop new biosensor-based blood glucose monitoring systems for use by diabetics

* Joint venture concentrates complementary glucose monitoring technologies of Medisys and Elan into one company

* Medisys licenses its re-usable blood glucose monitoring product, Arrow, to joint venture, accelerating the development programme and shortening Arrow's route to market

* Medisys retains technology rights to all of its other biosensor based monitoring applications, including its other blood glucose monitoring systems

* Joint venture acquires minimally invasive, continuous monitoring technology from Marathon Medical Technologies, Inc.

* Subscription by Elan for US$22 million (£13.9 million) of redeemable preferred shares to fund the acquisition of technologies and product development in the joint venture

* Subscription by Elan for 6,072,874 new Medisys ordinary shares at a price of 31.25p per share raising £1.9 million, for the general corporate purposes of Medisys

* Todd C. Davis of Elan, appointed to the Medisys board as a non-executive director

Kurt E. Amundson, President and Chief Operating Officer of Medisys said: "This partnership will create a new company with a strong technology portfolio and the capability to build a leading position in the market for blood glucose monitoring systems. Combining our joint technology and marketing resources is expected to accelerate the development of our Arrow product and enhance our future product pipeline. Elan's experience will also be invaluable in helping Hypoguard increase its penetration of the important U.S. market.

"The continuous monitoring technology acquired from Marathon will form the basis for the next generation of glucose monitoring products, placing Hypoguard at the forefront of glucose monitoring innovation."

Steve Thornton, Executive Vice President, Commercial Development, of Elan Pharmaceutical Technologies, said, "Hypoguard has an excellent pedigree as an innovator in the field of glucose monitoring and I am pleased we have been able to conclude a technology licensing deal with such a strong development partner."



To: nigel bates who wrote (884)2/5/2002 3:04:02 PM
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elan.com



To: nigel bates who wrote (884)2/5/2002 3:08:28 PM
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DOV Pharmaceuticals is lovey-dovey with neurotransmitter receptors. The development-stage firm focuses on therapies primarily for central nervous system conditions. Lead drug candidate NBI-34060 may treat insomnia by targeting the same subset of neurotransmitter receptors affected by Valium and Xanax, but with more specificity to avoid side effects associated with those drugs. DOV is working with Neurocrine Biosciences on the candidate. Biovail licensed cardiovascular candidate Diltiazem's patent from the biotech as part of its ploy to keep Andrx from gaining approval for its generic version of Biovail's blood-pressure drug Tiazac. DOV's 80%-owned joint venture with Elan is developing an anxiety drug.



To: nigel bates who wrote (884)2/5/2002 3:17:08 PM
From: Icebrg  Read Replies (1) | Respond to of 2243
 
OK, that was 20 pages worth of Google search on Elan+joint+venture. I am finished. No doubt there is much more.

Isn't it interesting that so much energy is spent on the accounting (although perfectly correct and legal) and so little on what might come out of all these research and development projects?

Ice