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Biotech / Medical : Trickle Portfolio -- Ignore unavailable to you. Want to Upgrade?


To: tuck who wrote (1062)2/13/2002 11:51:21 AM
From: tuck  Read Replies (1) | Respond to of 1784
 
>>PRINCETON, N.J., and OSS, Netherlands, Feb. 13 /PRNewswire-FirstCall/ -- Pharmacopeia, Inc. (Nasdaq: PCOP - news) and Organon, the pharmaceutical business unit of Akzo Nobel (EURONEXT: AKZ, Nasdaq: AKZOY) today announced the formation of a new 5-year drug discovery collaboration.

Under the terms of this agreement, Organon will provide Pharmacopeia with numerous biological test systems, or assays. Utilizing these assays, its broad collection of unique and powerful drug discovery technologies, and medicinal chemistry expertise, Pharmacopeia will seek to identify and optimize drug candidates for multiple targets that meet specific potency, selectivity, efficacy and other criteria. Pharmacopeia will license these optimized drug candidates to Organon.

In return for its successful drug discovery activities, and meeting additional preclinical and clinical milestones, Pharmacopeia will be entitled to receive fees and milestone payments from Organon. Upon successful commercialization of any product resulting from this relationship, Pharmacopeia will be entitled to receive royalties on sales of that product.

Pharmacopeia and Organon have enjoyed a successful relationship for many years. In addition to this new relationship, the two companies continue to collaborate on the optimization of Pharmacopeia's small molecule antagonists of the IL-8 CXCR2 receptor. IL-8 is a chemokine responsible for the recruitment of white blood cells to sites of injury resulting in inflammation. Blocking the IL-8 CXCR2 receptor may represent an important opportunity in treating certain inflammatory diseases. Pharmacopeia originally identified lead compounds in this program and began collaborating with Organon in January 2000 to further optimize these candidates.

``We are excited to announce a new collaboration with such a longstanding partner,'' said Joseph A. Mollica, Ph.D., Chairman, President and CEO of Pharmacopeia. ``This multi-year arrangement with our colleagues at Organon allows us to integrate our various drug discovery technologies and holds us responsible for delivering specific tangible results to Organon to augment their existing research activities. We are confident that we will achieve the specific research goals set for us by our partner and look forward to sharing in the scientific and financial success of these programs as they move through development. We are also pleased that Organon continues to aggressively pursue our IL-8 program and we confidently await Organon's selection of a formal development candidate.''

``We are pleased to continue our relationship with Pharmacopeia in our drug discovery program,'' said Driek Vergouwen, Managing Director R&D at Organon. ``This collaboration reflects our research ambition to benefit from advanced drug discovery technologies and approaches, not only within our own research organization, but also by strategic alliances with specialized key players such as Pharmacopeia.''<<

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Cheers, Tuck



To: tuck who wrote (1062)3/1/2002 1:14:12 AM
From: tuck  Read Replies (3) | Respond to of 1784
 
AGNT: update of BIO CEO and earnings CCs, with more color on the Jones Chromatography munch.

Having done cost cutting to the tune of 13% of its work force in the prior quarter, but still with a lot of cash, AGNT went hunting for a munch that would create a complete menu for chemists. AGNT found Jones, a private Irish company that is a slow, steady grower (low teens); since they've had no access to public capital markets that strategy has been required. Cash flow positive, it has a sales presence in Europe that should speed AGNT's entry into that market. Of the 118 employees, 11 are in the US, half of them sales reps. Yet the US accounted for 1/3 of Jones' revenue. They have roughly 10 folks doing direct sales in the UK, but use distributors on the continent. The munch is accretive to earnings, and the up front cash is only 30% of the total deal, with the other 60% to be paid over the next two years, and the remaining 10% in stock.

The munch drastically changes the mix at AGNT. Consumables will go from 20% to 35% to 41% ('00 to '01 to '02) of revenue. The mostly cash deal finesses goodwill issues that seem to be plaguing companies that munched with stock these days. However, there is goodwill write down coming from the Camille munch, from about 5 to 7 million, to be disclosed in the 10-K as a one time charge (no longer amortized per FASB 121).

In the quarter, consumables were 23% and instruments 67%, with the remaining 10% in service revenue.

The Surveyor/Endeavor line accounted for 21%, the Quest for 22%, the Trident for 14%, while other instruments made up the remaining 10%. Geographically, the US accounted for 70% of sales, Europe 20%, and Japan 10%.

Earnings were ahead of Q3 guidance by a few hundred thousand. Gross Margins were 41% for the quarter, impacted by the cost cutting. Also adding to expenses were a period of paying dual rent while moving, as well as R&D consulting for process control enhancements to some of the instruments (this last doesn't sound like a one-time item to me, though).

AGNT says they are in fact working on four projects with Pfizer, so more could come out of that collaboration than originally anticipated. A new revenue line, "contract research" will reflect revenue from Pfizer under that deal. The first product launch from that deal will be before year end. Jones was munched for near term diversification and extended sales reach, but in the long term (12 - 18 months), there will be some systems integration of the two companies' products.

Guidance: My notes from last year said breakeven about now. Given the life science CapEx blahs, the goodwill write down (versus amortization no longer allowed by FASB), and cost cutting charges(800K in charges: 320K of that related to work force reduction, the rest inventory write offs), that has now been pushed out over a year to the second half of '03. Ouch, I guess that's why it's trading where it is!

Jones GMs are 49%, AGNT expects '02 margins for the company as a whole to be 46%. CapEx to be ~$22 million. Assuming Jones is munched by the end of February (recent PR says it was done by the 20th), revenue including Jones for the month of March and on is expected to be $30 to $32 million. The mix is expected to be 47% instruments, over 40% consumables, 6% service, and 6% contract research from Pfizer. Net loss expected to be $8 to $9 million. For Q102 revenue $4.5 to $4.8 million and a loss of $2.7 to $3 million. Having munched Jones quickly, AGNT now has about 250 employees.

AGNT is trading for less than cash. Subtract roughly $5 million for the initial munch from the $57.6 million given in the table, and and bump the shares up to about 20 million for the 10% in stock for the munch and option exercises, etc. You still get about $2.50/share. If one assumes that biotechs and pharmas will one day -- maybe even soon -- buy equipment, this seems very cheap to me -- not to mention the theory that consumables keep selling even during capex slowdowns. I bought a little AGNT a few days ago at $2.35.

Next up: tomorrow or next week, DPII, BDAL, and IVGN (assuming IVGN doesn't charge long distance to hear their conference call, particularly annoying since they're based in my town!)

Cheers, Tuck