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Biotech / Medical : Indications -- Psoriasis/Chronic Inflammation -- Ignore unavailable to you. Want to Upgrade?

To: aknahow who wrote (179)	3/10/2002 10:13:40 AM
From: Icebrg	Read Replies (4) \| Respond to of 631

Psoriasis drugs under development I ran across the following "table" and thought it might be of interest to some of the readers on the thread. There is a lot going on in this area. I have done some re-editing and re-sorting to make the information more readable (hopefully). psoriasis-netz.de The information seems to be fairly recent, although not completely up-to-date. If Rick thinks it could be of interest, we might even (collectively) try to keep it updated as the various programs advances or collapses. Ice Under review. Enbrel (etanercept) Immunex/ Wyeth-Ayerst Anti-TNF (tumor necrosis factor) Drug filed with FDA for treating psoriatic arthritis (now approved) Amevive (alefacept) Biogen Fusion protein that binds to a key receptor on T cells Filed for FDA approval Panretin (alitretinoin) Ligand Pharmaceuticals Topical gel, vitamin A derivate phase IV Phase III. Remicade (infliximab) Centocor Anti-TNF (tumor necrosis factor) drug phase III (psoriasis) Tazorac (tazarotene) Allergan Oral version of topical vitamin A derivate phase III Targretin (bexarotene) Ligand Pharmaceuticals Oral vitamin A derivate phase III Xanelim (efalizumab) Genentech/Xoma Monoclonal antibody against T-cell receptor (CDIIa) phase III Phase II. ABX-IL8 Abgenix Monoclonal antibody against interleukin 8 (cytokine) phase II ADL 2-1294 Adolor Opiate for pain and itching phase II Elidel (pimecrolimus) Novartis Oral anti-inflammatory phase II Hectoral (doxicalciferol) Bone Care International Oral vitamin D derivate phase II HuMax-CD4 Genmab A/S Monoclonal antibody against T-cell receptor (CD4) phase II IDEC-114 IDEC Pharmaceuticals Monoclonal antibody against molecule (CD80) on antigen presenting cells phase II complete IDEC-131 IDEC Pharmaceuticals Monoclonal antibody against T-cell receptor (CD40L) phase II ISIS 2302 ISIS Pharmaceuticals Topical agaings molecule (ICAM-1) on antigen presenting cells phase II MEDI-507 Medimmune Monoclonal antibody against T-cell receptor (CD2) phase II Neovastad (AE-941) Aeterna Angiogenesis inhibitor phase II complete Ontak Ligand Pharmaceuticals Interleukin-2 (cytokine) fusion toxin phase II complete Paclitaxel Angiotech Pharmaceuticals Topical angiogenesis inhibitor phase II Panretin (alitretinoin) Ligand Pharmaceuticals Oral vitamin A derivate phase II PEN203 CoPharma, Inc. Topical antiproliferative phase II PVAC Corixa Systemic immune-system modifier phase II SMART Anti-Gamma Interferon Protein Design Labs Neutralizes inflammatory protein phase II VAS972 Vasogen Immunomodulator that treats blood removed from body in a medical device and returns it to the body phase II Verteporfin QLT Photo Therapeutics Light sensitizer used with UV exposure phase II Zenapax (daclizumab) Protein Design Labs Monoclonal antibody against T-cell receptor (CD25) phase II Zorcell (IR502) Immune Response Causes immune system to shut down activated T cells phase II complete Phase I and I/II. 5GI.I Alexion Pharmaceuticals Anti-inflammatory complement inhibitor phase I complete BCX 1777 Biocryst Blocks enzyme (PNP) needed vor T-cell division; topical oral drug for treatment of psoriasis phase I/II BIRB 796 Boehringer Ingelheim Oral drug for treatment of psoriasis phase I/II Combrestatin A4 Prodrug (CA4P) OXiGENE, Inc. Angiogenesis inhibitor phase I complete IC 747 ICOS Blocks T-cell receptor (LFA-I) phase I ISA(TX) 247 Isotechnika Systemic immunosuppressant phase I MDX-44 Medarex Monoclonal antibody that targets activated macrophages phase I/II PH-10 Photogen Technologies, Inc. Light sensitizer used with green light phase I Simulect Novartis Blocks interleukin-2 receptors; transplant drug phase I ST630 Penederm Topical vitamin D derivate phase I complete VIMRxyn Nexell Therapeutics Light sensitizer phase I & II VX148 Vertex Pharmaceuticals Inhibits an enzyme (IMDH) that activates immune system cells phase I complete Preclinical. BCI 202 Bone Care International Vitamin D derivate preclinical CellCept (mycophenolate mofetil) Roche Laboratories systemic immunosuppressant Investigator-initiated trials only phase ? Anti-IFG antisense oligonucleotide Centree for Hormone Research (Australia) Blocks IFG, a protein involved in promoting skin-cell growth preclinical Psorgone Nascent Pharmaceuticals Topical antiproliferative (stems keratinocyte growth) preclinical