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To: Joe Krupa who wrote (9036)	3/16/2002 2:44:27 PM
From: axial	Respond to of 14101

Hi, Joe - I think this comes from your neck of the woods... copernic.com ...it IS a great search engine. __________________________________________________ "...free time and patience" I am somewhat disturbed by the phenomenon at SH, WRT distortion, attacks on posters known for their credibility, and the constant repetition of thinly-disguised lies. Some of these posters take advantage of the normal courtesy that we extend to others: the assumption that the poster is acting out of sincere interest, be it positive or negative. In effect, the logical and factual voices are being constantly attacked - by the malicious and distorted posts of others. All, of course, under the guise of civility. *Bullsht. It's about time we started calling a spade a spade.** The info-danger in all stocks with emerging potential is the middle ground. The extreme positives and negatives are pretty obvious. It's that grey, unclear middle area that the FUD artists prosper - and we have quite a collection of them on SH. Any additional facts that can be brought to the dialogue are needed, now. I am probably spending more time than I should on this effort, but haven't all the longs done this, at one time or another? In any case, your thanks are appreciated. Best regards, Jim

To: Joe Krupa who wrote (9036)	3/17/2002 5:48:06 AM
From: axial	Read Replies (1) \| Respond to of 14101

Hi, Joe - After 10 hours of researching topicals for OA, and other uses, the following conclusions: 1 - Yes, there are a number of competitors, but none with the efficacy of Pennsaid. This is particularly true in Europe. Euro medications of this type seem to be predominantly prescriptive, though there is a large number of non-prescription products. I am wondering if Euro resistance isn't more political, than product-based. Needs more investigation. 2 - The "thinking" in the Canadian establishment on the subject (topical app of NSAIDs) seems to be way behind the curve. I can definitely see the need for a Canadian sales force. 3 - Knowledge of Pennsaid is low. Almost nonexistant. It's not yet on anyone's radar. 4 - The most important benefit of J+J (I'll say it again) will be building brand recognition, and market share. ________________________________________________________ Email sent...to jr2.ox.ac.uk Hello - I am wondering why you have no information on Pennsaid. This is a topical, transdermal system using DMSO to introduce diclofenac to the site of pain. Relief is very quick. Systemic effects are minimal. It is distributed in the UK by Provalis. This is a safe, effective product. I feel you are doing an injustice to those who suffer from chronic osteoarthritic pain: the potential for significant relief is noteworthy. I hope you will be able to correct this omission. Thank you _________________________________________________________ Thank heaven for FDA. Jim