Meanwhile, BDAL announces its Pittcon launches. Some surprises here, such as the genotyping accessory, the MALDI upgrade, and the very cheap MALDI unit. They got the Biacore product out the door quite quickly, as well. The high R&D spending at work.
>>NEW ORLEANS--(BW HealthWire)--March 18, 2002--Bruker Daltonics Inc. (NASDAQ: BDAL - news) today announces six major product introductions for mass spectrometry-based life science systems at the 2002 PittCon. In addition, Bruker Daltonics releases significant new software capabilities for three of its bioinformatics products. All products and releases are being shown at the Bruker Daltonics Pittcon booth (#965), and detailed press releases for the trade press and scientific journals are available.
``We are kicking off our new product introductions for 2002 with some very significant new systems, solutions and bioinformatics tools for expression proteomics, interaction proteomics, and for functional genomics,'' commented Frank Laukien, Ph.D., President and CEO. ``I am really pleased with the pace of innovations-turned-into-products coming from our R&D teams and partners, and I believe that these novel and often unique products will be very useful for our pharmaceutical/biotech and academic research customers.''
He continued: ``Demand and funding for our products continues to grow worldwide, as life-science research funding is shifting from gene sequencing, DNA/RNA expression arrays, and high-throughput screening towards genetic variation, expression proteomics, functional and structural proteomics, as well as metabolomics. This is a logical progression in the post-genomic era, and also a new emphasis on high information content, data quality and biological knowledge gain, rather than just throughput. We expect that these funding trends in drug discovery and life-science research will continue to benefit our growth well into the future.''
HIGHEST PERFORMANCE MALDI-TOF SYSTEM FOR PROTEOMICS
Bruker Daltonics introduces the ultraflex(TM) MALDI-TOF system, setting a new standard for the ultimate performance in MALDI-TOF mass spectrometry for proteomics and other applications.
The ultraflex offers even higher resolution than our previous top-of-the-line research MALDI-TOF, the reflex IV.
Using our proprietary designs, such as the unique gridless ion source, gridless reflectron, and patented AnchorChip(TM) technology, the ultraflex delivers the highest sensitivity for proteomics.
The ultraflex is an integral part of our Proteineer(TM) suite, and uses industry-standard microtitre plate-sized AnchorChip targets. It can be equipped with an optional robot for unattended 24/7 operation.
The ultraflex is the only high-performance MALDI-TOF that is upgradable to full TOF/TOF capability for unparalleled protein characterization capabilities. Our ultraflex TOF/TOF was introduced in July 2001, and began commercial shipments in Q4 of 2001.
COMPACT AFFORDABLE FTMS FOR ULTRA-HIGH RESOLUTION AND UNSURPASSED MASS ACCURACY IN SMALL MOLECULE ANALYSIS
Our FTMS group introduces the APEX(TM) IV, an innovative small-footprint very high-performance ESI-FTMS system. At $495,000, the APEX IV is affordable for customers who require ultra-high resolution and unsurpassed mass accuracy, e.g. in metabolomics, combinatorial library analysis, natural products elucidation, and other applications.
The APEX IV offers excellent sensitivity, MSn capabilities, ultra-high resolution and unsurpassed mass accuracy with a high-field actively-shielded 4.7 Tesla magnet.
Its intuitive handling, high degree of automation and more compact design make the APEX IV an ideal ultra-high resolution ESI-MS/MS system for LC/FTMS, or with a liquid-handling robot for flow-injection analysis.
BIACORE AND BRUKER DALTONICS INTRODUCE SPR/MS SYSTEM
Our R&D collaboration with Biacore, announced last November, has now resulted in the introduction of a complete commercial system for SPR/MS. Our unique SPR/MS technical solution adds the functional information obtained using Biacore's surface plasmon resonance (SPR) technology to proteomics databases, allowing researchers to correlate functional information with protein identification and characterization data obtained from mass spectrometry.
The combined semi-automatic SPR/MS technical solution is co-marketed by Biacore and Bruker Daltonics, and consists of
a Biacore 3000 SPR system
a map II/8 liquids handling robot for AnchorChip MALDI-target preparation
an autoflex(TM) MALDI-TOF mass spectrometer
ProteinScape(TM) bioinformatics and proteomics warehousing software, integrating the functional SPR data on protein-protein or protein-ligand interactions with MS data on protein identification and characterization
AFFORDABLE MALDI-TOF FOR BIOLOGISTS & CLINICAL RESEARCHERS
Bruker Daltonics is introducing the omniflex(TM) LT to provide an easy-to-use and affordable system for sensitive and accurate MALDI-TOF mass measurements of various biomolecules in clinical and diagnostic research, as well as other biology laboratories.
The omniflex LT is a bench-top MALDI-TOF system that is designed as a biologist-friendly molecular mass measurement tool.
Priced at only $89,900, the omniflex LT sets a new standard of affordability for a high-quality, automated large molecule mass reader.
The omniflex LT offers a complete set of AnchorChips, MALDI calibrants, assays, training tools and applications support for novice and walk-up users.
GENOTYPING MODULE FOR FUNCTIONAL GENOMICS
Our new GenoLink(TM) represents an important new solution for semi-automated SNP genotyping by MALDI-TOF. This accessory can now be provided to MALDI-TOF customers who are focused primarily on proteomics. Providing both protein and SNP information to our MALDI-TOF customers facilitates functional genomics research into the correlation between genes, genetic variation and proteomic expression.
GenoLink offers the benefits of virtually 100% accuracy and direct label-free SNP genotyping that have made MALDI-TOF essentially a ``gold-standard'' for human medical applications in pharmacogenomics and diagnostic research.
GenoLink is a semi-automated accessory for post-PCR clean-up and AnchorChip preparation for autoflex or ultraflex customers focused primarily on proteomics.
GenoLink is based on our map II/pure liquids handling workstation.
Data analysis in GenoLink is performed by GenoTools(TM) bioinformatics software.
For high-throughput or dedicated MALDI-TOF genotyping systems, we recommend our strategic partners, Sequenom and Variagenics.
MALDI-CAPABILITIES FOR ESQUIRE ION TRAP AND BIOTOF-Q SYSTEM
In order to provide MALDI capabilities to our ion trap and Q-q-TOF mass spectrometry customers, Bruker Daltonics introduces a novel atmospheric-pressure MALDI accessory for our research-grade esquire3000plus ion trap and BioTOF Q-q-TOF systems.
The MALDI accessory can be attached to the esquire3000plus or BioTOF-Q without breaking vacuum to obtain MALDI-MS and MS/MS spectra.
Changeover between ESI and MALDI operation is straightforward, and can be accomplished quickly and without tools.
This new MALDI accessory is intended for researchers who desire medium-throughput MALDI-MS/MS capabilities at intermediate sensitivity levels.
Its unique high mass range of m/z 3000 with simultaneous isotopic resolution on peptides make the esquire3000plus the ideal MALDI ion trap. For singly-charged MALDI ions, this means that the esquire3000plus is the only ion trap system on the market to provide isotopic full-scan resolution for typical tryptic peptides up to 3000 Daltons - a significant advantage for all ion trap proteomics researchers.
NEW BIOINFORMATICS CAPABILITIES FOR PROTEOMICS
Bruker Daltonics announces major enhancements to its innovative ProteinScape software, the company's integrated bioinformatics solution for comprehensive proteomics data warehousing and analysis, along with significant new releases of two other life-science software solutions.
ProteinScape provides a web-based platform for storing, organizing and analyzing data generated in the entire workflow of our Proteineer proteomics solution, including data relating to separation techniques, such as gel images, spot coordinates and spot characteristics; MS, MS/MS spectra and peak lists; library search results based on different sequence databases generated by different search engines; interpreted structural modifications like cross links, post-translational modifications, etc.
biotools(TM) release 2.1 for protein data interpretation provides unprecedented support to mass spectrometry-based protein analysis, including automated protein identification via library search and automated, user-defined routines to manage the analysis of large numbers of protein identifications using MALDI-TOF fingerprints, MALDI-TOF/TOF and LC-MS/MS data.
HyStar(TM) release 2.2 for chromatography and hyphenated experiments supports the complete LC/MS setup for our esquire ion traps, apex Fourier transform mass spectrometers, and BioTOF Q-q-TOF mass spectrometers. Hystar 2.2 now supports the Agilent 1100 LC and CE systems, the Dionex/LC-Packings UltiMate capillary LC-system, and the Waters CapLC system and Alliance LC-systems.<<
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BiaCore adds a little color . . .
>>UPPSALA, Sweden and BILLERICA, Mass., March 18 /PRNewswire-FirstCall/ -- Biacore International AB (Nasdaq: BCOR; SSE) and Bruker Daltonics Inc. (Nasdaq: BDAL - news) today announced that their recent collaboration to develop and commercialize a combined SPR-MS technology platform has already achieved two significant milestones.
Research material has now been published that demonstrates the principle of combining Biacore's Surface Plasmon Resonance with Bruker Daltonics' Mass Spectrometry in a model system. In addition, the first steps have been taken to integrate SPR-derived functional information with mass spectrometric identification and characterization data in new ProteinScape software.
Scientists working from both companies have already successfully demonstrated the principle of the combined technique of SPR-MS using a model system. Their work is summarized in a Biacore Application Note and Scientific Poster, both of which will be on display at this year's PITTCON conference in New Orleans, March 17-22.
In addition, the Bruker Daltonics stand (Pittcon Stand no. 965) will feature a demo version of the new ProteinScape software. This bioinformatics software package, for comprehensive proteomics data warehousing and analysis, was developed in collaboration with leading pharmaceutical and proteomics research companies. The new version has been updated as part of the collaboration to uniquely include Biacore's functional SPR data on protein-protein or protein-ligand interactions, as well as Bruker Daltonics' MS data on protein identification and characterization.
Clive Seymour, Vice President and Head of Life Science Research Business Unit at Biacore, commented, ``SPR's high quality kinetic and affinity data of known and suspected interactants, confirmed by MS, has huge potential benefits for rational or smart proteomics research. The ability of a proteomics database based on MS data, 2D data and SPR data to aid the user in determining which proteins are of the most immediate interest will create a major step forward in proteomics research.''
Dr. Michael Schubert, European Director of R&D at Bruker Daltonics, said: ``We are delighted to have already achieved this important first step in commercializing the combined technique of SPR-MS. We envisage that the technology platform will help pharmaceutical and biotech companies fast track targets for validation and enable more rapid development of therapeutic compounds.''<<
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Cheers, Tuck |
