To: Dnorman who wrote (7985 ) 5/2/2002 11:48:18 AM From: Bucky Katt Read Replies (1) | Respond to of 48467 GNLB had some interesting news yesterday, surprised no one mentioned it. They still have some things that could turn out to be big in the fire... The problem is bio-tech is an unloved sector at this time, which is good & bad..Good time to buy, bad if you hold from higher (much) levels. GNLB is ok technically.Genelabs Technologies, Inc. (Nasdaq: GNLB - news) announced today that it has entered into a collaboration with the University of Iowa Research Foundation (UIRF) to study the impact of the hepatitis G virus (HGV, also known as GB virus C, or GBV-C) on human immunodeficiency virus (HIV) infection. On September 6, 2001, Jack T. Stapleton, M.D., Professor of Medicine at the University of Iowa Roy J. and Lucille A. Carver College of Medicine and Director of the Helen C. Levitt Center for Viral Pathogenesis and Disease, and his colleagues published "Effect of Coinfection with GB Virus C on Survival Among Patients with HIV Infection" in the "New England Journal of Medicine" (Xiang, et. al., NEJM 2001; 345:707-714). Dr. Stapleton's research showed that patients infected with both HIV and GBV-C had a significantly reduced mortality rate compared to those infected only with HIV. Mortality of HIV-infected patients over the 4.1-year mean duration of the study was 28.5% for those with an HGV infection compared to 56.4% for those without HGV infection (p<0.001). This study confirmed previous reports suggesting delayed progression of HIV in patients coinfected with HGV and, furthermore, found that the infectious HGV clone developed by the University of Iowa research group inhibited the growth of HIV in a cell culture model. Dr. Stapleton stated, "Our findings may have implications for future treatments for HIV. I am pleased to be working with Genelabs and look forward to expanding upon our studies elucidating the role HGV may play in increasing survival of HIV-infected patients." Through the collaboration, Genelabs has granted UIRF a nonexclusive research license to Genelabs' HGV patent portfolio and the parties have exchanged research materials. Because of the potential importance of the University of Iowa's observations showing improved survival for HIV patients who also have an HGV co-infection, UIRF and Genelabs will make research licenses and materials available at no cost to other academic institutions interested in further scientific research in this area. Genelabs scientists first discovered HGV, which is transmitted by blood and other bodily fluids, while seeking to identify what was then an unknown hepatitis virus. Patents covering the HGV genome, peptides and their uses have issued to Genelabs. Since the discovery of HGV was announced by Genelabs in 1995, HGV infection has not been associated with any significant disease. The virus has been reported to be found in approximately 2 percent of all blood donated in the United States, in 15 percent of people infected with hepatitis C, and as high as 40 percent of people infected with HIV. Genelabs has previously granted diagnostics licenses for HGV to Boehringer Mannheim (now Roche Diagnostics), Chiron Corporation and Ortho Diagnostic Systems. Genelabs retains all other commercial rights to its discovery of HGV.