Silicon Investor (SI) -- The First Internet Community

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Biotech / Medical : PROTEOMICS -- Ignore unavailable to you. Want to Upgrade?

To: nigel bates who wrote (422)	6/10/2002 6:30:17 AM
From: nigel bates	Respond to of 539

Genomeweb article on the limitations of the structural approach - genomeweb.com SAN DIEGO, June 6 - A sizable contingent of researchers are working to uncover the rules of protein folding, but a growing number of scientists believes unfolded proteins may be just as important. "Not all proteins are the nice three-dimensional structures we are used to seeing; many functional proteins are intrinsically unstructured," Peter Wright, chairman of molecular biology at The Scripps Research Institute, said during a "protein disorder" session here at the Beyond Genomes conference. "This is a major challenge of structural biology and genomics." This is the first time the conference has held a protein-disorder track. The change can be traced to the critical mass of new data that points to the prevalence and importance of unstructured proteins, said Keith Dunker, the session chair and professor of biochemistry and biophysics at Washington State University The proteins comprising eukaryotes have large disordered, or unfolded, regions in more than half of their proteomes, said Zoran Obradovic, director of Temple University's Center for Information Science and Technology, and a speaker at the conference. These proteins are in a state other than the classic 3D structure believed by many researchers to be necessary for the "lock and key" model of protein interaction, explained Dunker. Instead, these protein sections may be completely unfolded, partly folded, momentarily folded, or in a state somewhere in between though still able to interact and regulate a cell's function...