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Biotech / Medical : Indications -- Psoriasis/Chronic Inflammation -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (243)	7/7/2002 12:50:10 PM
From: scaram(o)uche	Read Replies (1) \| Respond to of 631

[ more alpha4beta7 ] haven't done an exhaustive search, just wandered across this....... United States Patent 6,410,781 Konradi , et al. June 25, 2002 -------------------------------------------------------------------------------- .alpha.-aminoacetic acid derivatives-.alpha.4.beta.7 receptor antagonists Abstract Disclosed are compounds which bind .alpha..sub.4.beta..sub.7 integrin. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by .alpha..sub.4.beta..sub.7 integrin. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis. -------------------------------------------------------------------------------- Inventors: Konradi; Andrei W. (San Francisco, CA); Pleiss; Michael A. (Sunnyvale, CA); Thorsett; Eugene D. (Half Moon Bay, CA) Assignee: Elan Pharmaceuticals, Inc. (S. San Francisco, CA) patft.uspto.gov