To: JOEBT1 who wrote (1306 ) 7/26/2002 2:09:36 PM From: scaram(o)uche Read Replies (1) | Respond to of 2243 Joe: I haven't looked at Aphton for a couple of years, but I once took a close look. I can only comment, therefore, on the stuff that once made me nervous...... 1. It's not easy to break self-tolerance. Is there independent validation that anti-gastrin responses are actually induced? Who did the independent serology, if it's been done? 2. Before it was popular to bash Imclone, I used to lump the two companies together..... trials that aren't designed to provide clear results. Maybe they've improved the design? Are there monotherapy arms? from the prospectus........Philip C. Gevas, Chairman of the Board of Directors, President and Chief Executive Officer, has served as Director, President and Chief Executive Officer since co-founding Aphton in 1981. Mr. Gevas conceived and directed the development of Aphton's inventions which have resulted in numerous patents for Aphton for the treatment of colorectal, pancreatic, liver, esophageal, stomach and prostate cancers, and for GERD. After serving as an officer in the United States Air Force, Mr. Gevas has experience in the defense industry in management, science and engineering. Mr. Gevas has the degrees of M.E., and M.S. Mathematics (Stevens Institute of Technology) and M.S.E.E. (Ohio State University). Twenty one years. How can a biotech have existed for 21 years with one project? How can a biotech have existed for 21 years without providing much evidence of serological expertise? How could they have been around for 21 years, and yet NEVER published a single piece of original research? What is "experience in the defense industry"? Given that background, how did he become the inventor re. anti-gastrin? Sorry, can't really help you. It might be great, for all I know. But why would one develop interest in the first place?