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Biotech / Medical : Elan Corporation, plc (ELN) -- Ignore unavailable to you. Want to Upgrade?


To: scaram(o)uche who wrote (3335)10/3/2002 9:29:34 AM
From: scaram(o)uche  Read Replies (2) | Respond to of 10345
 
no meat here, just posting as tickler for those who have access to the journal......

Nat Rev Neurosci 2002 Oct;3(10):824-8

Opinion: Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning.

Schenk D.

Dale Schenk is at Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, California 94080, USA. dale.schenk@elan.com

The agents that are available at present for the management of Alzheimer's disease treat only the symptoms of neurodegeneration and, at best, result in modest, short-term improvements in cognitive function. Immunotherapy represents one of the first tests of the amyloid hypothesis in the clinic, and is an evolving approach to the treatment of Alzheimer's disease that offers a genuine opportunity to modify disease progression. Although initial clinical trials of one approach met with some setbacks, active or passive immunization holds great potential for treating or even preventing Alzheimer's disease.