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Gold/Mining/Energy : Nuvo Research Inc -- Ignore unavailable to you. Want to Upgrade?

To: TheBusDriver who wrote (11283)	10/26/2002 2:10:53 AM
From: russet	Read Replies (1) \| Respond to of 14101

You asked,...(ggggggggg) What is Pennsaid?,...well it's a combination of 5 things that are available in any pharmacy that are very cheap and off patent,...or other places like university labs,... Pennsaid® (1.5% w/w diclofenac sodium topical solution) contains: dimethyl sulphoxide, ethanol, glycerine, propylene glycol, purified water. Dissolving a 200 mg or so NSAID pill (these pills are just Na or K salts) in distilled water and mixing it with a equal volume of DMSO and applying it to a sore joint does work to relieve pain,...I've tried it and the literature suggests that many others have too). If the NSAID forms a cloudy solution when the DMSO is added, try adding a few drops of ethanol which acts as a solubilizer (ethanol is alcohol,...like in Vodka, rum etc). Addition a ml or so of propylene glycol, a polyalcohol that has uses as a skin softener (and antifreeze) makes it closer to the Pennsaid formula. Propylene glycol also could enhance DMSO absorption of the NSAID through the dermal layer as it can disrupt molecular interactions in skin and cell proteins making it easier for the NSAID to pass through the dermal layer. Propylene glycol is used in trandermal patches to facilitate absorption of a medicine through the skin and into the blood stream. Propylene glycol is in a lot of creams found in the pharmacy. Glycerine is a 1,2,3 Trihydroxy propane, a trihydric alcohol. It is a skin softener as well like propylene glycol. The pharmacist has this on his/her shelf too. It is used in a lot of high priced soaps said to moisturize the skin. Most NSAID molecules I have looked up are not much bigger than Diclofenac used in Pennsaid. Cox 2 NSAIDs are small molecules as well. Aspirin is very small, and Tylenol is too. My guess is any NSAID would be sucked through the skin by DMSO alone, but addition of a little propylene glycol would probably help. As far as the formula for Cox 2 inhibitors like Viox or Celebrex,...I could tell you but it is a chemical synthesis that requires a lot of lab equipment and intelligence to do,....between you and me,...I think I would be wasting my time. Good luck with your investments!