To: Biomaven who wrote (7563 ) 12/20/2002 1:05:08 PM From: rkrw Respond to of 52153 Also this one, announced after the close yesterday. This is a 50/50 deal between ENDP and PPCO. Nice reaction today for ppco. Endo Pharmaceuticals Submits New Drug Application For Extended Release Oxymorphone Utilizing Penwest's TIMERx Technology Thursday December 19, 6:19 pm ET - Submission Represents Important Milestone for Penwest PATTERSON, N.Y., Dec. 19 /PRNewswire-FirstCall/ -- Penwest Pharmaceuticals Co. (Nasdaq: PPCO - News) announced today that Endo Pharmaceuticals Inc. submitted a New Drug Application (NDA) to the US Food and Drug Administration for oxymorphone extended release tablets. Oxymorphone ER is an oral extended- release opioid analgesic that was jointly developed with Endo for the treatment of moderate to severe pain in patients requiring continuous, around- the-clock opioid therapy for an extended period of time. ADVERTISEMENT "Oxymorphone ER is our lead development program and we are very excited that the NDA has been submitted to the FDA. We believe oxymorphone ER is an excellent example of how the TIMERx® technology can add value to medicines for both consumers and our partners," said Tod Hamachek, Chairman of the Board and Chief Executive Officer. If approved oxymorphone ER, would give physicians and their patients an important new option for managing chronic pain with twice-daily dosing, and would compete in the growing, approximately $2 billion market for long-acting oral opioids. Mr. Hamachek went on to say, "This has been an exciting year for Penwest. With an agreement to sell our excipient business to Rettenmaier announced in the fourth quarter together with the oxymorphone ER filing, we have made great strides toward executing on our strategy of establishing Penwest as a specialty pharmaceutical business." The filing is based on a development program involving more than 2,400 patients.