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Biotech / Medical : Neuroscience -- Ignore unavailable to you. Want to Upgrade?


To: dalroi who wrote (243)1/5/2003 9:51:44 AM
From: scott_jiminez  Respond to of 278
 
<<3mg group seems to do beter then the 6mg or is this just a statistical flucke >>

I read the data as 3 mg and 6 mg being statistically equivalent since they both differ from placebo at the same level of significance. Recall there is always scatter in data: thus the 3 mg dose results are probably something like 0.7 +/- 0.2 and the 6 mg dose is likely 1.1 +/- 0.25. In other words, there overlap in the results from the 2 doses (i.e. there's no statistical 'fluke' because there no statistical difference).

These data suggest the antibody dose had already maxed out at 3 mg.



To: dalroi who wrote (243)1/5/2003 10:44:36 AM
From: Biotech Jim  Read Replies (2) | Respond to of 278
 
Stefaan-

My read is that the study is not sufficiently powered to draw conclusions regarding potential differences between the 3 and 6 mg groups. As to whether the response has maxed out, I do not think we can say that either due to the same rationale.

BJ