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Biotech / Medical : SARS and Avian Flu -- Ignore unavailable to you. Want to Upgrade?

To: Biomaven who wrote (70)	4/10/2003 2:30:11 PM
From: Biomaven	Respond to of 4232

From the CDC: The efficacy of available antiviral therapies against coronavirus infection is unknown. Ribavirin is a known teratogen, and clinicians who use it should be aware of all potential adverse events, including severe hemolytic anemia (9). Preliminary results from in vitro testing indicate that ribavirin concentrations that inhibit ribavirin-sensitive viruses do not inhibit replication or cell-to-cell spread of the novel coronavirus (JW Huggins, U.S. Army Medical Research Institute of Infectious Diseases, personal communication, 2003). However, further in vitro testing of antiviral drugs on other coronavirus isolates, and more information on the clinical outcomes of patients treated with ribavirin or other antiviral drugs in controlled trials is needed. cdc.gov But note that ribavirin is thought to have some in vivo anti-viral effects that might not show up in this in vitro test.