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Biotech / Medical : SARS and Avian Flu -- Ignore unavailable to you. Want to Upgrade?

To: chomolungma who wrote (349)	4/23/2003 3:11:06 PM
From: Biomaven	Read Replies (1) \| Respond to of 4232

A diagram of how the sequence of the SARS virus compares with some existing coronaviruses is shown in the following NEJM article: content.nejm.org The caption to the picture is as follows: In Panel C,a phylogenetic tree shows relations among coronavirus polymerase gene fragments (corresponding to BNI-1)according to the neighbor-joining method.The maximum likelihood method revealed the same rela- tions (data not shown).Genetic distances are indicated by the lengths of the branches.Analyses were performed on a bootstrapped data set (100 replicates).In addition to the coronavirus isolate FFM-ic,avian infectious bron- chitis virus (IBR31131),bovine coronavirus (AF220295), human coronavirus 229E (12175745),murine hepatitis virus (9629812),porcine epidemic diarrhea virus (19387576),and porcine transmissible gastroenteritis coronavirus (13399293)were included in the analysis. This particular diagram shows SARS as closest to Avian infectious bronchitis virus, but almost the same distance from the Bovine coronavirus and the Murine hepatitis virus. So it shows it as a likely cross between the Avian and one of these two, and quite distant from existing human coronaviruses. An earlier version from a different article I saw seemed to have it close to another coronavirus group as well, but maybe I misread the diagram at that time. Peter