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Biotech / Medical : Biotech Valuation -- Ignore unavailable to you. Want to Upgrade?

To: rkrw who wrote (8233)	5/1/2003 9:20:25 AM
From: Biomaven	Respond to of 52153

(Mostly OT) Published online before print April 30, 2003 Proc. Natl. Acad. Sci. USA, 10.1073/pnas.1035720100 Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake ( caloric restriction \| hippocampus \| insulin \| -hydroxybutyrate \| ketosis ) R. Michael Anson , Zhihong Guo , Rafael de Cabo, Titilola Iyun, Michelle Rios, Adrienne Hagepanos, Donald K. Ingram, Mark A. Lane , and Mark P. Mattson Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224 Edited by Anthony Cerami, The Kenneth S. Warren Institute, Kitchawan, NY, and approved March 25, 2003 (received for review October 18, 2002) Dietary restriction has been shown to have several health benefits including increased insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The mechanism remains unknown, but the need for a long-term reduction in caloric intake to achieve these benefits has been assumed. We report that when C57BL/6 mice are maintained on an intermittent fasting (alternate-day fasting) dietary-restriction regimen their overall food intake is not decreased and their body weight is maintained. Nevertheless, intermittent fasting resulted in beneficial effects that met or exceeded those of caloric restriction including reduced serum glucose and insulin levels and increased resistance of neurons in the brain to excitotoxic stress. Intermittent fasting therefore has beneficial effects on glucose regulation and neuronal resistance to injury in these mice that are independent of caloric intake. Sort of interesting that some religions etc. have regular fast days. Personally I'd say that being hungry every other day of your life isn't a good exchange for a longer life. More on topic, I wonder what the mechanisms involved might be? It would be interesting to see a gene microarray analysis of these mice. Peter