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Biotech / Medical : SARS and Avian Flu -- Ignore unavailable to you. Want to Upgrade?

To: Torben Noerup Nielsen who wrote (791)	5/12/2003 8:55:06 AM
From: scaram(o)uche	Read Replies (2) \| Respond to of 4232

Torben: Can you cite the source of your information re. rhinoviruses. It's news to me that they can escape the adaptive IR, and "A rhinovirus infection generally doesn't last long enough to fully stimulate the adaptive immune response" sounds just plain silly to me. Thanks. Just don't want a bit of foul dogma here, if indeed it's foul. With SARS, we may be at liberty to talk fowl dogma. Rick

To: Torben Noerup Nielsen who wrote (791)	5/12/2003 9:39:27 AM
From: Biomaven	Read Replies (1) \| Respond to of 4232

Torben, My belief is that the adaptive immune response kicks in too late to be of much use against a particular rhinovirus infection, but you do get 1-2 years of immunity against that particular strain. (The immunity is not life-long because it is primarily IgA based which degrades over months, not years). Here's a typical discussion: The primary infection results in IgA in nasal secretions and IgG in the bloodstream. Since these viruses do not enter the circulation, the mucosal IgA response is the most important. This leads to immunity and resolution of the disease although the levels of nasal IgA are rapidly reduced. Immunity against a particular serotype may last 1 to 2 years but as noted above there are many serotypes against which protection is not gained. med.sc.edu:85/virol/rhino.htm Peter