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Biotech / Medical : Millennium Pharmaceuticals, Inc. (MLNM) -- Ignore unavailable to you. Want to Upgrade?

To: Elmer who wrote (1518)	5/14/2003 10:08:58 AM
From: scaram(o)uche	Read Replies (2) \| Respond to of 3044

Ah, shucks, I get first shot at this easy (ha!) question? Yes, I do. But, I don't think that it will look like magic. The trials will be large and expensive, and MLN341 will look like other chemotherapeutics..... modest efficacy with pronounced toxicity. IMO, it will be another step toward having a cocktail of therapeutics that make chronic diseases of solid cancers. Twenty years..... biotech will have turned solid cancers into "autologous parasites", where the cancers will be occasionally beaten back by selective poisoning, malignancy > patient.

To: Elmer who wrote (1518)	5/14/2003 7:25:38 PM
From: Miljenko Zuanic	Respond to of 3044

Elmer, First I love when Rick first take shot. So, I can choose my words more carefully. <g> ƒº Dozen indicators suggest that V will be sinergistic with chemo, and play rule in solid tumor combination(s) therapy. One good indicator (from those who are in field) is investigators and NCI entuziazm visible by V cancer trials numbers and speed they are enrolling pts and completing trials. As I mentioned early, ASCO will help to better project (at this time it is hard) V utility in other cancer type (CC, NSCLC, PS, RCC, OC, ¡K). Do I believe that V will work. Yes, I do. But, what I believe and what is real word can be like sky and land, far, far away. One more thing. Usually drug that work for hematology cancer does not work as good in solid tumors. Velcade may be excluded, based on mode of action. It is and will be toxic to all cells, but IF one can show me one BROAD chemo agent without toxicity I will change my mind. Miljenko