Silicon Investor (SI) -- The First Internet Community

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Biotech / Medical : Cambridge Antibody Technology Group -- Ignore unavailable to you. Want to Upgrade?

To: nigel bates who wrote (359)	5/14/2003 5:32:06 PM
From: nigel bates	Respond to of 625

Never heard of them, but Lonza signed a 12 month technology evaluation deal with them last June, and CAT is a Lonza customer. United States Patent 5,891,691 Hadlaczky April 6, 1999 ------------------------------------------------------------------------ Method of producing a cell carrying an excess of mammalian centromeres and the cell line carrying an excess of mammalian centromeres Abstract DNA fragments and methods for obtaining them are disclosed which when put into mammalian cells together with a dominant marker gene are able to form functional centromeres. The sequences can be used to generate probes for these centromeres. Cell lines containing the functional centromeres are also provided. Methods are taught for isolating mammalian centromeric DNA as well as for producing cell lines carrying an excess of mammalian centromeres linked to a dominant selectable marker gene. ------------------------------------------------------------------------ Inventors: Hadlaczky; Gyula (Szeged, HU) Assignee: The Biological Research Center of the Hungarian Academy of Sciences (HU) Appl. No.: 734344 Filed: October 21, 1996 ... ------------------------------------------------------------------------ United States Patent 6,077,697 Hadlaczky , et al. June 20, 2000 ------------------------------------------------------------------------ Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes Abstract Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided. ------------------------------------------------------------------------ Inventors: Hadlaczky; Gyula (Szamos, HU); Szalay; Aladar A. (Highland, CA) Assignee: Chromos Molecular Systems, Inc. (CA); The Biological Research Center of the Hungarian Academy of Sciences (HU) Appl. No.: 682080 Filed: July 15, 1996