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Biotech / Medical : Indications -- Psoriasis/Chronic Inflammation -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (428)	6/17/2003 10:29:39 AM
From: nigel bates	Respond to of 631

BAFF; also known as TALL-1, THANK, BlyS, and zTNF4 Gotta have something to hide with so many aliases.

To: scaram(o)uche who wrote (428)	6/17/2003 3:26:05 PM
From: nigel bates	Respond to of 631

Or both ? United States Patent 6,475,987 Shu November 5, 2002 ------------------------------------------------------------------------ Tall-1 receptor homologues Abstract The amino acid and nucleic acid sequence of a protein expressed by monocytes and macrophages, called TALL-1, are disclosed. Homologues, mimetics and antibodies that bind to TALL-1 are disclosed. Also disclosed is the TALL-1 receptor, and homologues of such receptor. The invention includes methods for regulating the interaction between TALL-1 and its receptor and for identifying compounds capable of such regulation. The invention also includes methods for regulating B lymphocyte proliferation, activation, and/or survival. ------------------------------------------------------------------------ Inventors: Shu; Hong-Bing (Denver, CO) Assignee: National Jewish Medical and Research Center (Denver, CO) Appl. No.: 565423 Filed: May 5, 2000 Current U.S. Class: 514/12; 435/69.1; 530/350; 536/23.5 Intern'l Class: A61K 038/00 Field of Search: 530/350 536/23.5 514/12 435/69.1 ------------------------------------------------------------------------