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Biotech / Medical : Tularik Inc. (TLRK) -- Ignore unavailable to you. Want to Upgrade?

To: Czechsinthemail who wrote (493)	7/17/2003 1:25:51 AM
From: scaram(o)uche	Respond to of 598

FEBS Lett. 2003 Jul 17;547(1-3):157-61. Characterization of Pellino2, a substrate of IRAK1 and IRAK4. Strelow A, Kollewe C, Wesche H. Tularik Inc., 1120 Veterans Boulevard, South 94080, San Francisco, CA, USA Interleukin-1 (IL-1) receptor-associated kinases (IRAKs) are central components of Toll/IL-1 receptor (TIR) signaling pathways. In an attempt to discover novel signal transducers in TIR signaling, we identified human Pellino2 as an interaction partner of IRAK4. Pellino2 interacts with kinase-active as well as kinase-inactive IRAK1 and IRAK4. Furthermore, Pellino2 is one of the first substrates identified for IRAK1 and IRAK4. Functional studies using overexpression or RNAi knock-down of Pellino2 suggest a role of Pellino2 as a scaffolding protein similar to Pellino1. However, unlike Pellino1, Pellino2 does not seem to activate a specific transcription factor, but links TIR signaling to basic cellular processes.