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Biotech / Medical : Cambridge Antibody Technology Group -- Ignore unavailable to you. Want to Upgrade?


To: nigel bates who wrote (385)9/3/2003 4:46:16 AM
From: nigel bates  Respond to of 625
 
Cambridge Antibody Technology and Xerion Pharmaceuticals Expand Alliance Into Antibody Drug Development

/PRNewswire-FirstCall/ -- Cambridge Antibody Technology (LSE: CAT;
Nasdaq: CATG) and Xerion Pharmaceuticals AG today announce that they have
entered into an agreement that paves the way for Xerion to develop and
commercialise human monoclonal antibody-based drugs. Under the terms of the
agreement, CAT has granted to Xerion options to take licences to develop and
commercialise antibodies derived from CAT's proprietary antibody phage display
libraries. These antibodies are directed against critical disease-associated
protein targets characterised using Xerion's proprietary Xstream(TM)
technologies. CAT will receive development based milestone payments and
royalties on antibody products developed by Xerion and its collaborators.
This agreement strengthens and expands the existing relationship between the
two companies established through a licence in June 2001 involving the
research use of CAT's proprietary antibody phage display libraries.
Subsequently, the companies initiated a joint research collaboration in 2002
to investigate the druggability of a target to treat allergic conditions.

Peter Chambre, CAT's Chief Executive Officer, commented: "We are impressed by Xerion's achievements to date with the CAT libraries and their continued commitment to target discovery and validation using our technology. The present agreement allows both parties to benefit from Xerion's strategy to build an antibody drug pipeline for itself and its partners."

"We are very pleased with today's extension of our relationship with CAT into drug development," said Markus Ewert, PhD, President and Chief Executive Officer of Xerion. "We have very successfully and to our full satisfaction integrated and applied CAT's human antibody libraries to identify key disease targets. Xerion now can truly exploit its integrated drug discovery platform, Xstream(TM), to further create and commercialise antibody therapeutic drugs. In this way, we expect to generate significant value for both companies." ...


...Xerion Pharmaceuticals is building a pipeline of novel therapeutic targets and antibodies. To identify targets, the Company uniquely focuses on proteins, using proprietary technologies to selectively block their function in diseased cells thereby mimicking the activity of a drug. Xerion integrates this approach with the ability to rapidly generate therapeutic antibody leads. The Company is developing these targets and antibodies independently and in conjunction with partners with an emphasis on cancer indications. For additional information, please visit our website at www.xerion-pharma.com.
* Xerion is headquartered in Martinsried, Germany and its subsidiary Xerion Pharmaceuticals Inc. is based in Cambridge, MA, USA. The Company has license and collaborative agreements with Altana Pharma AG, Arius Research Inc., Cambridge Antibody Technology Ltd., Procorde GmbH, Xoma Ltd., and several research institutes



To: nigel bates who wrote (385)9/3/2003 6:55:25 AM
From: nigel bates  Read Replies (1) | Respond to of 625
 
Two other deals announced today (Micromet & Enzon) - presumably hoping to dilute the disappointment at the lack of progress on the Humira royalty dispute:

Micromet, Enzon and Cambridge Antibody Technology sign Cross-Licence Agreement
in the Field of Single-Chain Antibodies and Phage Display

Expanded opportunities for the development of novel antibody therapeutic
products

Cambridge, UK, Munich, Germany and Bridgewater, NJ ... Cambridge Antibody
Technology (LSE:CAT; NASDAQ:CATG), Micromet AG (private), and Enzon
Pharmaceuticals, Inc. (NASDAQ:ENZN) today announce that they have signed a
non-exclusive cross-licence agreement, under which all three parties obtain
substantial freedom to conduct research under certain of each others'
intellectual property, as well as the right to develop a defined number of
therapeutic and diagnostic antibody-based products. CAT obtains expanded access
to Micromet's and Enzon's joint patent estate in the field of single-chain
antibody technology (SCA) and both Micromet and Enzon gain rights to
intellectual property in antibody phage display controlled by CAT.

This cross-licence agreement builds on existing alliances: that of Micromet and
Enzon, where both parties combined their significant patent estates and
complementary expertise in the field of SCAs; and the licence agreement first
entered into among CAT, Enzon and Creative BioMolecules in 1996. In addition to
the cross-licensing of intellectual property under this agreement, Enzon and CAT
have both agreed to withdraw their pending oppositions to each others' European
patents in the area of diabodies.

Under the terms of the agreement, Micromet and Enzon obtain the right within the
framework of their collaboration to use CAT's intellectual property in phage
display to create and

commercialise novel antibody products against a defined number of targets. In
addition, Enzon and Micromet each receive options to develop and commercialise
antibody products outside of their alliance. CAT receives options to develop and
commercialise diagnostic and therapeutic SCA products and broad rights to
SCA-based technologies for research, including the right to sublicense to
collaboration partners. In addition CAT receives a two-year option to licence
SCA technology for use in antibody microarrays. The cross-licence agreement is
structured to maximally incentivise all three parties to develop and
commercialise antibody-based products.

Christian Itin, PhD, Micromet's Chief Business Officer commented, 'The SCA IP
estate consolidated between Enzon and Micromet in 2002 and the CAT-MRC IP estate
to antibody phage display are robust in their respective spaces. The present
transaction provides each of the companies access to relevant complementary IP,
supporting each company's business case on attractive commercial terms.'

Peter Chambre, CAT's Chief Executive Officer, commented, 'We view this
cross-license agreement with Micromet and Enzon as important to our commitment
to the development and commercialisation of therapeutic antibodies. Not only
does CAT obtain access to a broad commercial opportunity in SCA, but through
this agreement CAT enjoys greater flexibility in respect of its collaboration
partners. All three companies stand to benefit from this consolidation of
intellectual property which underpins the exploitation of antibody-based drugs.'

Uli Grau, Enzon's Chief Scientific Officer, commented, 'With this cross-licence
Enzon is able to strengthen our leading position in the growing field of
antibody therapies, which we intend to leverage to expand our product
portfolio.'

-ENDS-


CAMBRIDGE ANTIBODY TECHNOLOGY ANNOUNCES PRODUCT LICENCE AGREEMENT WITH MICROMET AG

Micromet granted licence to commercialise therapeutic antibody product in cancer

Cambridge, UK Cambridge Antibody Technology Group plc (LSE: CAT;
NASDAQ: CATG) today announces the grant of a non-exclusive patent licence to
Micromet AG for the development and commercialisation of its proprietary human
therapeutic antibody candidate MT201. The antibody, developed using phage
display technologies controlled by CAT, is specific for the epithelial tumour
target EpCAM and has the potential to address a broad range of cancer
indications. MT201 is the subject of a co-development agreement with Novuspharma
SpA to jointly develop the candidate through a Phase II programme scheduled to
commence shortly.

Under the terms of the agreement with CAT, Micromet receives a worldwide licence
in respect to all CAT's antibody phage display technology patents, both pending
and granted, to develop antibody-based products targeting the EpCAM antigen. In
return, CAT will receive an upfront licence fee from Micromet as well as
milestone and royalty payments on human antibody-based products developed
against the EpCAM target by Micromet and its partners.

Peter Chambre, CAT's Chief Executive Officer, commented; 'We are very encouraged
by the commitment and progress made by Micromet in therapeutic antibody
development and are pleased that the company views a licence to CAT's antibody
phage display patents as fundamental to its investment in this area. CAT's
patent licensing strategy supports the growing enthusiasm for human
antibodies as an extremely important class of drug addressing major areas of
unmet medical need.'

Christian Itin, Chief Business Officer of Micromet, commented; 'CAT's
antibody phage display technology was critical to the generation of
MT201, a fully human IgG targeting EpCAM. The additional unique binding
properties of MT201 came about as a result of the innovative approaches to
display technology applied by Micromet researchers. We are looking forward with
our partner Novuspharma to entering the next phase of the clinical development
of MT201.'