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Biotech / Medical : Guilford (GLFD) - Steadily Rising -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (442)	9/10/2003 4:37:52 PM
From: scaram(o)uche	Respond to of 496

The "Durus Effect"? Long position gone, but the partnered naked short still hanging out there, very naked? Anybody know if SEC has tracked down his "working partners"?

To: scaram(o)uche who wrote (442)	9/11/2003 8:58:43 AM
From: scaram(o)uche	Read Replies (3) \| Respond to of 496

J Biol Chem. 2003 Sep 5 [Epub ahead of print]. Transcriptional coactivation of NF-kappa B-dependent gene expression by p300 is regulated by PARP-1. Hassa PO, Buerki C, Lombardi C, Imhof R, Hottiger MO. Institute of Veterinary Biochemistry and Molecular Biology, Zurich 8057. Nuclear factor kappaB (NF-kappaB) plays an important role in the transcriptional regulation of genes involved in inflammation and cell survival. Here, we demonstrate that NF-kappaB-dependent gene expression was inhibited by E1A in poly(ADP)-ribose polymerase-1 knock out (PARP-1 (-/-)) cells complemented with wild type PARP-1 after TNFalpha or LPS treatment. PARP-1 and p300 synergistically coactivated NF-kappaB-dependent gene expression in response to TNFalpha and LPS. Furthermore, PARP-1 interacted directly with p300 and enhanced the interaction of NF-kappaB1/p50 to p300. The C-terminus, harboring the catalytic domain of PARP-1 but not its enzymatic activity was required for complete transcriptional coactivation of NF-kappaB by p300 in response to TNFalpha and LPS. Together, these results indicate that PARP-1 acts synergistically with p300 and plays an essential regulatory role in NF-kappaB-dependent gene expression. (no direct relevance, that I know of, to anything ongoing at GLFD. Just parking.)