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To: gg cox who wrote (13013)	10/15/2003 10:41:57 PM
From: axial	Respond to of 14101

Hi gg - Thanks for the link. In researching the post speculating on how WF10 works, I've gone through literally hundreds of papers. If I've learned anything, it's to be careful of what people are saying when they speak of the immune system. Researchers speak of it in mechanistic terms, in biochemical terms, in terms of action, reaction, causation and effect. They speak of mediators effectors and transcriptases. They use terms that have different meanings at the same time, depending on who's using them, or the context. There's acquired (adaptive) immunity, cellular immunity, humoral immunity, inflammatory response, innate immunity, and allergy. The immune system can be activated classically or alternately and there are components of the immune system that are Janus-faced. Components can wear the White Hat or they can wear the Black Hat depending on a whole range of conditions and interactions that are only now beginning to be understood. The immune system can initiate an amazing cascade of responses to something as simple as nitric oxide, at the basic chemical level - which discovery caused researchers to receive the Nobel prize - and has stimulated the release of about 3,000 research papers a year. Free radicals, oxidative stress, reactive oxgen intermediates, reactive oxygen species.... Chemokines, receptors, interleukins.... My point? Even in the simple description of WF10 macrophage activation, there are deeper process at work. Such a description obscures as much as it reveals. Is macrophage activation, or alternate macrophage activation, the Chicken, or the Egg? So too, with the description in your link. It may be promising; one doesn't want to be negative. But it's possibly one of hundreds of such discoveries that have turned out to be an illusion fostered by a peculiar set of circumstances. The immune system confounds specificity. How does that relate to WF10? I don't think I've found the tree in the forest that represents WF10's mechanism of action. I don't think anyone has. But I think I've found which part of the forest the answer is in, and that leads me to say this: So far, there is nothing like WF10. Nothing. WF10 appears to be working at the same level as NO. You may have heard astronomers say, when they're speaking of a star at the edge of the universe, that we are looking at history when we watch that star - the light has taken millions of years to reach us. When we look at WF10, we're looking at the earliest history of the immune system. We're watching interactions at the most basic level: levels of energy and efficiency that predate the more sophisticated and complex interactions that evolved in human immune response. It may predate human response, even animal response. IMO, much of the research we see today is based on intermediate and tertiary processes, involving specificity and intermediate states that come later in the evolution of immune response. They deal with a subset of immune response. This research seems, at first glance, to lie in that area. Could it develop into something more profound? Yes. Of course it could. But based on this initial information, it doesn't appear to be anything like WF10, and what's more, in its present state at least, appears to be a less desirable alternative. So far, I have seen no IBT (Immune-Based Therapy) that matches the results obtainable with WF10. None. All IMO, of course. Jim